Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10890872 | 0.92 | LMNA (0.40) | LMNAALDH1A1MAPTMAPK1RECQL | |
| SCHEMBL11200754 | 0.92 | ALDH1A1 (0.39) | LMNAALDH1A1MAPTMAPK1RECQL | |
| SCHEMBL10899040 | 0.83 | ALDH1A1 (0.41) | LMNAALDH1A1MAPTRECQLPOLB | |
| SCHEMBL10881231 | 0.80 | LMNA (0.39) | LMNAALDH1A1MAPTMAPK1RECQL | |
| SCHEMBL9493016 | 0.79 | LMNA (0.50) | LMNAALDH1A1MAPTMAPK1RECQL | |
| SCHEMBL9493012 | 0.79 | LMNA (0.50) | LMNAALDH1A1MAPTMAPK1RECQL | |
| SCHEMBL9493024 | 0.77 | LMNA (0.40) | LMNAALDH1A1MAPTMAPK1RECQL | |
| SCHEMBL9494278 | 0.75 | LMNA (0.52) | LMNAALDH1A1MAPTMAPK1RECQL | |
| SCHEMBL9494274 | 0.75 | LMNA (0.52) | LMNAALDH1A1MAPTMAPK1RECQL | |
| SCHEMBL10899048 | 0.75 | ALDH1A1 (0.40) | LMNAALDH1A1MAPTRECQLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4582841-A | ANTITUMOR AND -CARCINOGENIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1986-04-15 | — | — | US | disclosed |
| US-4489069-A | ANTITUMOR | CIBA-GEIGY AG (CH) | 1984-12-18 | — | — | US | disclosed |