Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | CTSG | P08311 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11010732 | 0.75 | PDE4A (0.53) | HPGDKDM4EHSD17B10ALDH1A1GAA | |
| SCHEMBL10891718 | 0.71 | APP (0.46) | GUSBMGAMGAASIMGAM2 | |
| SCHEMBL7331775 | 0.70 | MAOA (0.43) | MAOAMAOBMGAMGAASI | |
| SCHEMBL30442890 | 0.69 | ALDH1A1 (0.67) | HPGDKDM4EHSD17B10MAOAALDH1A1 | |
| SCHEMBL29623192 | 0.69 | ALDH1A1 (0.67) | HPGDKDM4EHSD17B10MAOAALDH1A1 | |
| SCHEMBL28574 | 0.69 | ALDH1A1 (0.67) | HPGDKDM4EHSD17B10MAOAALDH1A1 | |
| SCHEMBL27659427 | 0.69 | ALDH1A1 (0.67) | HPGDKDM4EHSD17B10MAOAALDH1A1 | |
| SCHEMBL7319990 | 0.69 | KDM4E (0.67) | HPGDKDM4EHSD17B10BRD4ALDH1A1 | |
| SCHEMBL10843649 | 0.69 | PDE3B (0.42) | BRD4ALDH1A1TDP2NSD2TDP1 | |
| SCHEMBL10823691 | 0.68 | CASP3 (0.63) | HPGDKDM4EHSD17B10ALDH1A1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153209-A | Cardiotonic agents | GLAXO INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5051431-A | For treatment of congestive heart failure | GLAXO INC. (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0419286-A2 | Pyridone nitriles useful in treating cardiovascular disease | GLAXO WELLCOME INC. (US) | 1991-03-27 | — | — | EP | disclosed |