Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.41 |
| ▸ | FBP1 | P09467 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10891371 | 0.98 | APOBEC3A (0.47) | APOBEC3AAPOBEC3GPDK1FBP1JAK2 | |
| SCHEMBL1891504 | 0.74 | APOBEC3A (0.42) | APOBEC3AAPOBEC3GPDK1FBP1JAK2 | |
| SCHEMBL16695138 | 0.73 | SMN1; SMN2 (0.53) | APOBEC3AAPOBEC3GPDK1FBP1JAK2 | |
| Hydrochloric Acid SCHEMBL10891755 | 0.72 | NPC1 (0.36) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| SCHEMBL10893914 | 0.71 | ABL1 (0.44) | RAB9AMAPTABL1NPC1SMN1; SMN2 | |
| Evandamine SCHEMBL6009808 | 0.71 | APOBEC3A (0.42) | APOBEC3AAPOBEC3GPDK1FBP1JAK2 | |
| Hydrochloric Acid SCHEMBL10889776 | 0.70 | ABL1 (0.43) | RAB9AMAPTABL1NPC1SMN1; SMN2 | |
| SCHEMBL10890235 | 0.68 | TSHR (0.39) | RAB9AMAPTNPC1SMN1; SMN2POLB | |
| SCHEMBL12865380 | 0.68 | PIK3CD (0.59) | APOBEC3AAPOBEC3GPDK1FBP1RAB9A | |
| SCHEMBL558522 | 0.68 | APOBEC3A (0.95) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4600722-A | 3-amino-1-(4,5,6,7-tetrahydro-benzothiazolyl)-2-pyrazolines and a process for the treatment of inflammatory or allergic processes in humans | A. NATTERMANN & CIE GMBH (DE) | 1986-07-15 | — | — | US | claimed |
| EP-0155523-A1 | 3-Amino-1-(4,5,6,7-Tetrahydro-benzothiazolyl)-2-Pyrazolines,a process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-25 | — | — | EP | claimed |
| JP-60226878-A | — | — | None | — | — | JP | disclosed |
| US-4600722-A | 3-amino-1-(4,5,6,7-tetrahydro-benzothiazolyl)-2-pyrazolines and a process for the treatment of inflammatory or allergic processes in humans | A. NATTERMANN & CIE GMBH (DE) | 1986-07-15 | — | — | US | disclosed |
| US-4600722-A | 3-amino-1-(4,5,6,7-tetrahydro-benzothiazolyl)-2-pyrazolines and a process for the treatment of inflammatory or allergic processes in humans | A. NATTERMANN & CIE GMBH (DE) | 1986-07-15 | — | — | US | disclosed |
| US-4600722-A | 3-amino-1-(4,5,6,7-tetrahydro-benzothiazolyl)-2-pyrazolines and a process for the treatment of inflammatory or allergic processes in humans | A. NATTERMANN & CIE GMBH (DE) | 1986-07-15 | — | — | US | disclosed |
| JP-S60226878-A | 3-AMINO-1-(4,5,6,7-TETRAHYDROBENZOTHIAZOLYL)-2-PYRAZOLINES AND MANUFACTURE | NATTERMANN A & CIE | 1985-11-12 | — | — | JP | disclosed |
| EP-0155523-A1 | 3-Amino-1-(4,5,6,7-Tetrahydro-benzothiazolyl)-2-Pyrazolines,a process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-25 | — | — | EP | disclosed |
| EP-0155523-A1 | 3-Amino-1-(4,5,6,7-Tetrahydro-benzothiazolyl)-2-Pyrazolines,a process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-25 | — | — | EP | disclosed |
| EP-0155523-A1 | 3-Amino-1-(4,5,6,7-Tetrahydro-benzothiazolyl)-2-Pyrazolines,a process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-25 | — | — | EP | disclosed |