Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.95 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.95 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.54 |
| ▸ | FBP1 | P09467 | 2/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL4937558 | 0.98 | APOBEC3A (0.91) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| SCHEMBL1670074 | 0.98 | APOBEC3A (1.00) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| Hydrochloric Acid SCHEMBL27990499 | 0.98 | APOBEC3A (0.91) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| SCHEMBL4940807 | 0.98 | APOBEC3A (0.91) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| SCHEMBL26113827 | 0.98 | APOBEC3A (0.91) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| SCHEMBL23666043 | 0.98 | APOBEC3A (1.00) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| Hydrochloric Acid SCHEMBL27899743 | 0.98 | APOBEC3A (0.91) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| Iodide SCHEMBL4937555 | 0.96 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| Hydrochloric Acid SCHEMBL27906695 | 0.96 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GPDK1FBP1ADRA2A | |
| SCHEMBL624175 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 383 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111875615-A | Methoxybenzyl urea compound and application thereof | 济南大学 | 2020-11-03 | — | — | CN | claimed |
| CN-107935962-A | The preparation method of 6s n-pentyl Pramipexole impurity | 山东新华制药股份有限公司 | 2018-04-20 | — | — | CN | claimed |
| CN-105753812-B | The synthetic method of body of Pramipexole dihydrochloride intermediate | 赤峰赛林泰药业有限公司 | 2017-12-08 | — | — | CN | claimed |
| CN-105936628-A | Synthesis method of pramipexole hydrochloride intermediate | 赤峰赛林泰药业有限公司 | 2016-09-14 | — | — | CN | claimed |
| CN-103613562-B | Preparation method of pramipexole | ZHEJIANG MENOVO PHARMACEUTICALS Co.,Ltd. (CN) | 2015-09-30 | — | — | CN | claimed |
| CN-104177309-A | Preparation process for pramipexole | BEIJING KAIRUI KEDE DRUG TECHNOLOGY RES CO LTD | 2014-12-03 | — | — | CN | claimed |
| CN-103613562-A | Preparation method of pramipexole | ZHEJIANG MENOVO PHARMACEUTICALS CO LTD | 2014-03-05 | — | — | CN | claimed |
| CN-102442972-A | Industrial preparation method of pramipexole and dihydrochloride monohydrate thereof | JINAN FUCHUANG MEDICAL TECHNOLOGY CO LTD | 2012-05-09 | — | — | CN | claimed |
| US-8173638-B2 | Compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-08 | — | — | US | claimed |
| US-20110312935-A1 | 1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-12-22 | — | — | US | claimed |
| WO-2008064054-A2 | COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-05-29 | — | — | WO | claimed |
| JP-2007522171-A | — | — | 2007-08-09 | — | — | JP | claimed |
| US-20070027315-A1 | Substituted 4,5,6,7-tetrahydrobenzthiazol-2-ylamine compounds | GRUENENTHAL GMBH (DE) | 2007-02-01 | — | — | US | claimed |
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | claimed |
| EP-1716128-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2006-11-02 | — | — | EP | claimed |
| CN-1834092-A | Prepn. of pramipexole | JIANG NENGQIAO (CN) | 2006-09-20 | — | — | CN | claimed |
| WO-2005077924-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | Grünenthal GmbH (DE) | 2005-08-25 | — | — | WO | claimed |
| CN-1117564-C | Use of prumipexole in the treating of restless legs syndrome | UPJOHN CO (US) | 2003-08-13 | — | — | CN | claimed |
| WO-2000027394-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2000-05-18 | — | — | WO | claimed |
| CN-1243439-A | Use of prumipexole in the treating of restless legs syndrome | UPJOHN CO (US) | 2000-02-02 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312935-A1 | 1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents | MAPRE2, MAPRE1, H1-4 | APOBEC3A 4882/4885APOBEC3G 4855/4885PDK1 987/4885 |
| US-20060276496-A1 | Anti-Cytokine Heterocyclic Compounds | MAPKAPK2, MAP4K2, MAP3K2 | APOBEC3A 4799/4885APOBEC3G 4859/4885PDK1 446/4885 |
| US-20070027315-A1 | Substituted 4,5,6,7-tetrahydrobenzthiazol-2-ylamine compounds | TPH2, HTR6, TPH1 | APOBEC3A 4636/4885APOBEC3G 4410/4885PDK1 1136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.