Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | SLC27A1 | Q6PCB7 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 8/20 | 0.39 |
| ▸ | RAB9A | P51151 | 8/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10889776 | 0.99 | ABL1 (0.43) | ABL1TSHRHSD17B10LMNASLC27A1 | |
| SCHEMBL10890235 | 0.84 | TSHR (0.39) | TSHRHSD17B10LMNASLC27A1PARP1 | |
| SCHEMBL10890832 | 0.78 | NPC1 (0.37) | TSHRLMNASLC27A1PARP1NPC1 | |
| Hydrochloric Acid SCHEMBL10891755 | 0.77 | NPC1 (0.36) | TSHRLMNASLC27A1PARP1NPC1 | |
| SCHEMBL10888736 | 0.73 | PDK1 (0.33) | LMNASLC27A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL659214 | 0.72 | TSHR (0.71) | TSHRHSD17B10LMNAPARP1NPC1 | |
| SCHEMBL10891764 | 0.72 | MEN1 (0.45) | TSHRHSD17B10LMNASLC27A1NPC1 | |
| SCHEMBL10893459 | 0.71 | APOBEC3A (0.49) | ABL1TSHRLMNANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL10891371 | 0.70 | APOBEC3A (0.47) | ABL1TSHRLMNANPC1RAB9A | |
| SCHEMBL13035816 | 0.69 | TSHR (0.67) | TSHRHSD17B10LMNAPARP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4600722-A | 3-amino-1-(4,5,6,7-tetrahydro-benzothiazolyl)-2-pyrazolines and a process for the treatment of inflammatory or allergic processes in humans | A. NATTERMANN & CIE GMBH (DE) | 1986-07-15 | — | — | US | disclosed |
| EP-0155523-A1 | 3-Amino-1-(4,5,6,7-Tetrahydro-benzothiazolyl)-2-Pyrazolines,a process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-25 | — | — | EP | disclosed |