Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 9/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1090274 | 0.85 | CXCR4 (0.55) | ADRA2BADRA2CSLC6A2HRH2HTR1D | |
| SCHEMBL1090037 | 0.75 | L3MBTL1 (0.48) | KDM6B | |
| SCHEMBL2954351 | 0.75 | MKNK1 (0.55) | KDM6BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2954481 | 0.73 | GRIN2D (0.51) | KDM6BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL31681833 | 0.73 | NR2C2 (0.59) | KDM6BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2374912 | 0.73 | NR2C2 (0.59) | KDM6BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2373974 | 0.72 | GRIN2D (0.60) | KDM6BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL31681849 | 0.72 | GRIN2D (0.60) | KDM6BGRIN2DGRIN3BGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL6960891 | 0.69 | ADRA2B (0.48) | KDM6BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1264610 | 0.69 | HDAC6 (0.54) | KDM6BGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120156219-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-06-21 | — | — | US | disclosed |
| US-8153625-B2 | Nitrogen-containing heterocyclic compounds and medicinal use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-04-10 | — | — | US | disclosed |
| US-20100221259-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-09-02 | — | — | US | disclosed |
| US-7759336-B2 | Nitrogen-containing heterocyclic compounds and medicinal use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-07-20 | — | — | US | disclosed |
| US-20070167459-A1 | Nitrogen-containing heterocyclic compounds and medicinal use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-07-19 | — | — | US | disclosed |
| EP-1571146-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100221259-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | CXCR4, CXCL12, CXCR3 | KDM6B 2597/4885GRIN2D 3441/4885GRIN3B 1305/4885 |
| US-20070167459-A1 | Nitrogen-containing heterocyclic compounds and medicinal use thereof | CXCR4, CXCL12, CXCR3 | KDM6B 2597/4885GRIN2D 3441/4885GRIN3B 1305/4885 |
| US-20120156219-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | CXCR4, CXCL12, CXCR3 | KDM6B 2597/4885GRIN2D 3441/4885GRIN3B 1305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.