Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10901738 | 0.88 | NPC1 (0.42) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL10901966 | 0.82 | HTR2C (0.44) | GABRA1GABRG2GABRB3KMT2ASLC6A4 | |
| SCHEMBL10899848 | 0.79 | HRH4 (0.40) | HTR3A | |
| SCHEMBL10902053 | 0.78 | HTR2C (0.48) | KMT2AHTR1AHTR2C | |
| SCHEMBL3509594 | 0.78 | GABRA1 (0.48) | GABRA1GABRG2GABRB3KCNH2BCHE | |
| SCHEMBL10900555 | 0.77 | PLG (0.35) | GABRA1GABRG2GABRB3HTR2C | |
| SCHEMBL2874838 | 0.75 | PLG (0.38) | GABRA1GABRG2GABRB3BCHEACHE | |
| Hydrochloric Acid SCHEMBL10321362 | 0.74 | HTR2C (0.39) | GABRA1GABRG2GABRB3BCHEACHE | |
| SCHEMBL10902522 | 0.73 | CDC7 (0.40) | GABRA1GABRG2GABRB3SLC6A4BCHE | |
| SCHEMBL10902292 | 0.73 | MPO (0.41) | KCNH2SLC6A4SLC6A2SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4210655-A | Anti-depressant benzofuranyl piperidines | CIBA-GEIGY CORPORATION (US) | 1980-07-01 | — | — | US | claimed |
| EP-0011606-A2 | Pharmaceutical compositions with central depressing and antipsychotic activity | CIBA-GEIGY AG (CH) | 1980-05-28 | — | — | EP | claimed |
| US-4600719-A | Tetrahydropyridine and piperidine derivatives | CIBA GEIGY CORPORATION (US) | 1986-07-15 | — | — | US | disclosed |
| US-4284638-A | Pharmaceutical compositions with central depressant and antipsychotic activity having a butyrophenone derivative which is substituted in the 4-position and a C-(2-benzofuranyl)-piperidine or C-(2-benzofuranyl)-tetrahydro-pyridine | CIBA-GEIGY CORPORATION (US) | 1981-08-18 | — | — | US | disclosed |
| US-4210655-A | Anti-depressant benzofuranyl piperidines | CIBA-GEIGY CORPORATION (US) | 1980-07-01 | — | — | US | disclosed |
| EP-0011606-A2 | Pharmaceutical compositions with central depressing and antipsychotic activity | CIBA-GEIGY AG (CH) | 1980-05-28 | — | — | EP | disclosed |