Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.45 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11467969 | 0.83 | ALOX5 (0.55) | MAP4K4SMN1; SMN2RAB9ANPC1ALOX5 | |
| SCHEMBL5322145 | 0.83 | MAP4K4 (0.66) | MAP4K4SMN1; SMN2RAB9ANPC1DHFR | |
| SCHEMBL2616121 | 0.83 | SMN1; SMN2 (0.54) | MAP4K4SMN1; SMN2RAB9ANPC1ALOX5 | |
| SCHEMBL13563179 | 0.81 | KCNQ3 (0.49) | MAP4K4IDO1TAAR1KCNQ3KCNQ2 | |
| SCHEMBL817554 | 0.81 | ALOX5 (0.65) | SMN1; SMN2RAB9ANPC1ALOX5IDO1 | |
| SCHEMBL31222672 | 0.81 | ALOX5 (0.65) | SMN1; SMN2RAB9ANPC1ALOX5IDO1 | |
| SCHEMBL11172794 | 0.79 | CYP2A6 (0.58) | MAP4K4SMN1; SMN2RAB9ANPC1ALOX5 | |
| SCHEMBL2609379 | 0.79 | MAP4K4 (0.48) | MAP4K4SMN1; SMN2RAB9ANPC1ALOX5 | |
| SCHEMBL17826988 | 0.79 | MAPT (0.50) | MAP4K4SMN1; SMN2RAB9ANPC1ALOX5 | |
| SCHEMBL27684280 | 0.78 | ATM (0.54) | MAP4K4ALOX5CNR2IDO1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105461699-B | Substituted heterocyclic compound and its application method and purposes | 广东东阳光药业有限公司 | 2019-07-09 | — | — | CN | disclosed |
| US-20110251169-A1 | Arylethynyl derivatives | HOFFMANN-LA ROCHE, INC. | 2011-10-13 | — | — | US | disclosed |
| US-4613603-A | Compounds with a nitrogen-containing heterocyclic nucleus, and drugs in which they are present | SANOFI (FR) | 1986-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251169-A1 | Arylethynyl derivatives | GRM5, GRM1, GRM3 | MAP4K4 3356/4885SMN1; SMN2 3190/4885RAB9A 1170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.