Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 6/20 | 0.66 |
| ▸ | DHFR | P00374 | 1/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.57 |
| ▸ | CLK1 | P49759 | 2/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10898685 | 0.83 | MAP4K4 (0.50) | MAP4K4DHFRCLK1TDO2TAAR1 | |
| SCHEMBL2319381 | 0.81 | MAP4K4 (0.68) | MAP4K4DHFRADORA2AADORA1TDO2 | |
| SCHEMBL11467969 | 0.80 | ALOX5 (0.55) | MAP4K4DHFRTAAR1NPC1RAB9A | |
| SCHEMBL2616121 | 0.80 | SMN1; SMN2 (0.54) | MAP4K4DHFRTAAR1NPC1RAB9A | |
| SCHEMBL2643156 | 0.79 | MAP4K4 (1.00) | MAP4K4NPC1RAB9A | |
| SCHEMBL5468823 | 0.79 | MAP4K4 (0.52) | MAP4K4DHFRADORA2AADORA1ADORA2B | |
| SCHEMBL20150481 | 0.78 | MAP4K4 (0.68) | MAP4K4DHFRADORA2ATAAR1 | |
| SCHEMBL31222672 | 0.78 | ALOX5 (0.65) | BACE1TAAR1JAK2NPC1RAB9A | |
| SCHEMBL817554 | 0.78 | ALOX5 (0.65) | BACE1TAAR1JAK2NPC1RAB9A | |
| SCHEMBL1388562 | 0.77 | DHFR (1.00) | MAP4K4DHFRADORA2AADORA1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096764-A2 | BICYCLIC HETEROARYL DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS | GLENMARK PHARMACEUTICALS S.A. (US) | 2007-08-30 | — | — | WO | disclosed |