Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.72 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.71 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.71 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.71 |
| ▸ | LTA4H | P09960 | 6/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10895401 | 1.00 | HRH3 (0.72) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| SCHEMBL10896960 | 0.98 | LTA4H (0.72) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| SCHEMBL491770 | 0.92 | HRH3 (0.82) | HRH3TSHR | |
| SCHEMBL5858552 | 0.91 | HRH3 (0.80) | HRH3TSHR | |
| SCHEMBL876980 | 0.89 | LTA4H (0.75) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| SCHEMBL5486360 | 0.88 | HRH3 (0.77) | HRH3TSHR | |
| SCHEMBL14393575 | 0.88 | LTA4H (0.67) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| SCHEMBL8122915 | 0.87 | HRH3 (0.80) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| SCHEMBL14970716 | 0.87 | HRH3 (0.80) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| Hydrochloric Acid SCHEMBL14966041 | 0.86 | HRH3 (0.78) | HRH3PSMB1PSMB5PSMB2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136202-A2 | COMPOUNDS AND METHODS FOR CDK8 MODULATION AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2018-07-26 | — | — | WO | disclosed |
| US-7300936-B2 | α-(N-sulfonamido)acetamide derivatives as β-amyloid inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-11-27 | — | — | US | disclosed |
| EP-0070133-B1 | SECONDARY PHENYLETHANOL AMINES, PROCESSES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL APPLICATION | BEECHAM GROUP PLC (GB) | 1986-05-14 | — | — | EP | disclosed |