Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.75 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.65 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.65 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL492409 | 0.93 | HRH3 (0.83) | LTA4HHRH3TSHR | |
| SCHEMBL19043080 | 0.92 | HRH3 (0.77) | LTA4HHRH3TSHR | |
| SCHEMBL17636032 | 0.91 | HRH3 (0.71) | LTA4HHRH3TSHRPSMB1PSMB5 | |
| SCHEMBL10896960 | 0.91 | LTA4H (0.72) | LTA4HHRH3TSHRPSMB1PSMB5 | |
| SCHEMBL10899705 | 0.89 | HRH3 (0.72) | LTA4HHRH3TSHRPSMB1PSMB5 | |
| SCHEMBL10895401 | 0.89 | HRH3 (0.72) | LTA4HHRH3TSHRPSMB1PSMB5 | |
| SCHEMBL13492993 | 0.88 | LTA4H (0.76) | LTA4HHRH3TSHR | |
| SCHEMBL873542 | 0.87 | ALDH1A1 (0.74) | LTA4HHRH3TSHR | |
| SCHEMBL9035011 | 0.87 | HRH3 (0.78) | HRH3TSHR | |
| SCHEMBL491770 | 0.85 | HRH3 (0.82) | HRH3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |