Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 12/20 | 0.40 |
| ▸ | MAOA | P21397 | 9/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10901806 | 0.84 | TLR9 (0.41) | DRD2SLC6A4ACHETLR7 | |
| SCHEMBL10901424 | 0.81 | QDPR (0.44) | DRD2SLC6A4TLR7BACE1 | |
| SCHEMBL10903335 | 0.79 | MAOB (0.44) | MAOBMAOADRD2SLC6A4 | |
| SCHEMBL10898362 | 0.77 | ABL1 (0.41) | TLR7 | |
| SCHEMBL10906165 | 0.77 | MAOB (0.38) | MAOBMAOA | |
| SCHEMBL10901484 | 0.76 | S1PR1 (0.44) | MAOBMAOAP2RY14DRD2SLC6A4 | |
| SCHEMBL10901664 | 0.75 | QDPR (0.42) | SLC6A4TLR7BACE1 | |
| SCHEMBL11336429 | 0.69 | MAOB (0.43) | MAOBMAOAP2RY14DRD2SLC6A4 | |
| SCHEMBL11334591 | 0.67 | CYP1A2 (0.43) | MAOBMAOAP2RY14DRD2 | |
| SCHEMBL81671 | 0.66 | MAOB (0.60) | MAOBMAOADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4210655-A | Anti-depressant benzofuranyl piperidines | CIBA-GEIGY CORPORATION (US) | 1980-07-01 | — | — | US | claimed |
| US-4600719-A | Tetrahydropyridine and piperidine derivatives | CIBA GEIGY CORPORATION (US) | 1986-07-15 | — | — | US | disclosed |
| US-4210655-A | Anti-depressant benzofuranyl piperidines | CIBA-GEIGY CORPORATION (US) | 1980-07-01 | — | — | US | disclosed |