Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 8/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10901424 | 0.81 | QDPR (0.44) | QDPRHRH4KCNH2HRH3BACE1 | |
| SCHEMBL10902522 | 0.78 | CDC7 (0.40) | SLC18A3SIGMAR1SLC6A4 | |
| SCHEMBL10902292 | 0.78 | MPO (0.41) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10901738 | 0.78 | NPC1 (0.42) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10902855 | 0.78 | HTR2C (0.44) | HTR2CCYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10901806 | 0.77 | TLR9 (0.41) | TLR9TLR8TLR7SLC6A4 | |
| SCHEMBL10898362 | 0.75 | ABL1 (0.41) | QDPRTLR9TLR8TLR7 | |
| SCHEMBL10901490 | 0.75 | MAOB (0.40) | BACE1TLR7SLC6A4 | |
| SCHEMBL3891711 | 0.75 | HTR2C (0.48) | HTR2C | |
| SCHEMBL10898355 | 0.75 | HTR2C (0.49) | HTR2CSIGMAR1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4600719-A | Tetrahydropyridine and piperidine derivatives | CIBA GEIGY CORPORATION (US) | 1986-07-15 | — | — | US | disclosed |
| US-4210655-A | Anti-depressant benzofuranyl piperidines | CIBA-GEIGY CORPORATION (US) | 1980-07-01 | — | — | US | disclosed |