Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10899817 | 0.88 | PDGFRB (0.48) | PDGFRBPDGFRACYP17A1CYP11B1CYP11B2 | |
| SCHEMBL10903355 | 0.80 | PDGFRB (0.47) | PDGFRBPDGFRANPC1RAB9AKDM4E | |
| SCHEMBL10902304 | 0.77 | NPC1 (0.40) | PDGFRBPDGFRACYP17A1NPC1RAB9A | |
| SCHEMBL10902026 | 0.76 | MKNK2 (0.43) | PDGFRBPDGFRANPC1RAB9AKDM4E | |
| SCHEMBL10902490 | 0.76 | KMT2A (0.43) | CYP17A1CYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL10899791 | 0.76 | MAPK14 (0.45) | CYP17A1CYP11B1CYP11B2MAPK14MAPK13 | |
| SCHEMBL10899410 | 0.74 | NPC1 (0.40) | NPC1RAB9AKDM4EMAPK14MAPK13 | |
| SCHEMBL10901779 | 0.73 | KIF11 (0.49) | NPC1RAB9AMAPK14MAPK13MAPK12 | |
| SCHEMBL10373029 | 0.72 | CYP2A6 (0.45) | NPC1RAB9AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL4514604 | 0.72 | CYP17A1 (0.76) | PDGFRBPDGFRACYP17A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4600719-A | Tetrahydropyridine and piperidine derivatives | CIBA GEIGY CORPORATION (US) | 1986-07-15 | — | — | US | disclosed |
| US-4210655-A | Anti-depressant benzofuranyl piperidines | CIBA-GEIGY CORPORATION (US) | 1980-07-01 | — | — | US | disclosed |