Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 3/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.66 |
| ▸ | CYP11B2 | P19099 | 12/20 | 0.65 |
| ▸ | CYP11B1 | P15538 | 11/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.63 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18770313 | 0.87 | CYP17A1 (1.00) | CYP17A1PDGFRBPDGFRACYP11B2CYP11B1 | |
| SCHEMBL3020390 | 0.86 | HSD17B1 (0.76) | CYP17A1CYP11B2CYP11B1CYP19A1CYP1A2 | |
| SCHEMBL11723032 | 0.85 | HSD17B1 (0.83) | CYP17A1CYP11B2CYP11B1CYP19A1CYP1A2 | |
| SCHEMBL12051687 | 0.85 | HSD17B1 (0.83) | CYP17A1CYP11B2CYP11B1CYP19A1CYP1A2 | |
| SCHEMBL6338303 | 0.84 | CYP17A1 (0.57) | CYP17A1PDGFRBPDGFRACYP11B2CYP11B1 | |
| SCHEMBL4094356 | 0.83 | KDM4E (0.71) | CYP17A1PDGFRBPDGFRACYP1A2CYP3A4 | |
| SCHEMBL29733664 | 0.83 | KDM4E (0.71) | CYP17A1PDGFRBPDGFRACYP1A2CYP3A4 | |
| SCHEMBL9612000 | 0.83 | LMNA (0.61) | CYP17A1PDGFRBPDGFRACYP11B2CYP11B1 | |
| SCHEMBL20664519 | 0.82 | HSD17B1 (0.70) | CYP17A1CYP11B2CYP11B1CYP19A1CYP1A2 | |
| SCHEMBL5981250 | 0.82 | HSD17B1 (0.70) | CYP17A1CYP11B2CYP11B1CYP19A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | UNIVERSITAT DES SAARLANDES (DE) | 2009-09-03 | — | — | US | claimed |
| EP-1853261-B1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | UNIV SAARLAND (DE) | 2017-01-11 | — | — | EP | disclosed |
| US-9271963-B2 | Selective inhibitors of human corticosteroid synthases | UNIVERSITAT DES SAARLANDES (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | UNIVERSITAT DES SAARLANDES (DE) | 2009-09-03 | — | — | US | disclosed |
| EP-1853261-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006092430-A1 | SELECTIVE INHIBITORS OF HUMAN CORTICOSTEROID SYNTHASES | Universität des Saarlandes (DE) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221591-A1 | Selective Inhibitors of Human Corticosteroid Synthases | CYP11B1, HSD11B1, HSD17B1 | CYP17A1 9/4885PDGFRB 2920/4885PDGFRA 4093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.