Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10901637 | 0.77 | PDGFRB (0.48) | NPC1RAB9APDGFRBPDGFRACYP1A2 | |
| SCHEMBL10899817 | 0.74 | PDGFRB (0.48) | NPC1RAB9APDGFRBPDGFRACYP1A2 | |
| SCHEMBL8297436 | 0.71 | SMN1; SMN2 (0.43) | NPC1RAB9APDGFRBPDGFRACYP1A2 | |
| SCHEMBL10906164 | 0.70 | NPC1 (0.40) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL8800060 | 0.70 | F2RL3 (0.47) | NPC1RAB9ATEKPDGFRBPDGFRA | |
| SCHEMBL10903355 | 0.69 | PDGFRB (0.47) | NPC1RAB9APDGFRBPDGFRACYP1A2 | |
| SCHEMBL10901530 | 0.67 | RAB9A (0.36) | NPC1RAB9APDGFRBPDGFRACYP1A2 | |
| SCHEMBL10902490 | 0.65 | KMT2A (0.43) | NPC1RAB9AKDM4ECYP17A1MAPT | |
| SCHEMBL2423594 | 0.64 | MAOA (0.51) | PDGFRBPDGFRACYP1A2CYP1A1CYP1B1 | |
| SCHEMBL21917154 | 0.64 | CHUK (0.44) | PDGFRBPDGFRACYP1A2CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4600719-A | Tetrahydropyridine and piperidine derivatives | CIBA GEIGY CORPORATION (US) | 1986-07-15 | — | — | US | disclosed |
| US-4210655-A | Anti-depressant benzofuranyl piperidines | CIBA-GEIGY CORPORATION (US) | 1980-07-01 | — | — | US | disclosed |