Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.40 |
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21638 | 0.91 | ALDH1A1 (0.54) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11250018 | 0.91 | ALDH1A1 (0.54) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11050413 | 0.91 | ALDH1A1 (0.41) | ALDH1A1TSHRKDM4ETDP1MEN1 | |
| Hydrochloric Acid SCHEMBL28099309 | 0.90 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ETDP1MEN1 | |
| Hydrochloric Acid SCHEMBL11567888 | 0.90 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ETDP1MEN1 | |
| Methane SCHEMBL28070367 | 0.90 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ETDP1MEN1 | |
| Bromide SCHEMBL3261137 | 0.90 | ALDH1A1 (0.52) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| Ethylene SCHEMBL28021132 | 0.90 | ALDH1A1 (0.52) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11250021 | 0.90 | ALDH1A1 (0.52) | ALDH1A1KDM4ETDP1MEN1KMT2A | |
| Water SCHEMBL8010252 | 0.90 | ALDH1A1 (0.52) | ALDH1A1KDM4ETDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4619744-A | SOLUBLE CROSSLINKABLE POLYELECTROLYTE | PHILLIPS PETROLEUM COMPANY (US) | 1986-10-28 | — | — | US | disclosed |