Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.69 |
| ▸ | AR | P10275 | 3/20 | 0.69 |
| ▸ | F2 | P00734 | 1/20 | 0.69 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | USP2 | O75604 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10902825 | 1.00 | PGR (0.69) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10910515 | 0.95 | PGR (0.67) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10910516 | 0.95 | PGR (0.67) | PGRCYP3A4ARF2NR3C1 | |
| Methylprednisolone Aceponate SCHEMBL3466 | 0.94 | PGR (0.74) | PGRCYP3A4ARF2NR3C1 | |
| Methylprednisolone Aceponate SCHEMBL8612416 | 0.94 | PGR (0.74) | PGRCYP3A4ARF2NR3C1 | |
| Methylprednisolone Aceponate SCHEMBL8961317 | 0.94 | PGR (0.74) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10906704 | 0.94 | PGR (0.79) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10906703 | 0.94 | PGR (0.79) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL11126257 | 0.94 | PGR (0.79) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10903110 | 0.93 | PGR (0.67) | PGRCYP3A4ARF2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0095894-A2 | 6 Alpha-methylprednisolone derivatives | OHTA SEIYAKU KABUSHIKI KAISHA. (JP) | 1983-12-07 | — | — | EP | claimed |
| US-4567172-A | ANTINFLAMMATORY AGENTS, ANTIALLERGENS | OHTA SEIYAKU KABUSHIKI KAISHA (JP) | 1986-01-28 | — | — | US | disclosed |