Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.67 |
| ▸ | AR | P10275 | 3/20 | 0.67 |
| ▸ | F2 | P00734 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | USP2 | O75604 | 3/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10910515 | 1.00 | PGR (0.67) | PGRNR3C1CYP3A4ARF2 | |
| SCHEMBL10900414 | 0.95 | NR3C1 (0.63) | PGRNR3C1CYP3A4ARF2 | |
| SCHEMBL10901354 | 0.95 | NR3C1 (0.68) | PGRNR3C1CYP3A4ARF2 | |
| SCHEMBL10906135 | 0.95 | NR3C1 (0.63) | PGRNR3C1CYP3A4ARF2 | |
| SCHEMBL10901349 | 0.95 | NR3C1 (0.68) | PGRNR3C1CYP3A4ARF2 | |
| SCHEMBL10906137 | 0.95 | NR3C1 (0.63) | PGRNR3C1CYP3A4ARF2 | |
| SCHEMBL10901075 | 0.95 | NR3C1 (0.65) | PGRNR3C1CYP3A4ARF2 | |
| SCHEMBL10901081 | 0.95 | NR3C1 (0.65) | PGRNR3C1CYP3A4ARF2 | |
| SCHEMBL10900405 | 0.95 | NR3C1 (0.63) | PGRNR3C1CYP3A4ARF2 | |
| Methylprednisolone Aceponate SCHEMBL8961317 | 0.95 | PGR (0.74) | PGRNR3C1CYP3A4ARF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4587236-A | Novel 6α-methylprednisolone derivatives, their preparation, and their use | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-05-06 | — | — | US | disclosed |