Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.45 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL27380337 | 1.00 | ALDH1A1 (0.60) | ALDH1A1LMNAKDM4ECYP2D6CYP1A2 | |
| Octadecylamine SCHEMBL27611582 | 0.86 | ALDH1A1 (0.44) | ALDH1A1LMNAKDM4ECYP2D6CYP1A2 | |
| Citric Acid SCHEMBL5874663 | 0.86 | ALDH1A1 (0.62) | ALDH1A1LMNAKDM4ECYP2D6CYP1A2 | |
| Citric Acid SCHEMBL5874658 | 0.86 | ALDH1A1 (0.62) | ALDH1A1LMNAKDM4ECYP2D6CYP1A2 | |
| Citric Acid SCHEMBL29562281 | 0.85 | DNM1 (0.52) | ALDH1A1LMNAKDM4ECYP2D6CYP1A2 | |
| Citric Acid SCHEMBL29600959 | 0.85 | DNM1 (0.52) | ALDH1A1LMNAKDM4ECYP2D6CYP1A2 | |
| Citric Acid SCHEMBL9814769 | 0.85 | DNM1 (0.52) | ALDH1A1LMNAKDM4ECYP2D6CYP1A2 | |
| Citric Acid SCHEMBL29600140 | 0.85 | DNM1 (0.52) | ALDH1A1LMNAKDM4ECYP2D6CYP1A2 | |
| Citric Acid SCHEMBL21219853 | 0.85 | DNM1 (0.52) | ALDH1A1LMNAKDM4ECYP2D6CYP1A2 | |
| Citric Acid SCHEMBL9439612 | 0.85 | DNM1 (0.52) | ALDH1A1LMNAKDM4ECYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1283768-C | A liquid laundry conditioning composition containing a fabric-softening silicone | PROCTER & GAMBLE (US) | 2006-11-08 | — | — | CN | disclosed |
| CN-1653168-A | Liquid detergent conditioning compositions comprising fabric softening silicone | PROCTER & GAMBLE (US) | 2005-08-10 | — | — | CN | disclosed |
| US-4631187-A | Hair treating composition containing a quaternary ammonium compound containing an erucyl group | S.C. JOHNSON & SON, INC. (US) | 1986-12-23 | — | — | US | disclosed |
| EP-0104653-A2 | Hair care composition | S.C. JOHNSON & SON, INC. (US) | 1984-04-04 | — | — | EP | disclosed |