Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.48 |
| ▸ | PTPRC | P08575 | 3/20 | 0.47 |
| ▸ | S100A4 | P26447 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PNMT | P11086 | 4/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1808330 | 0.87 | PTPRC (0.47) | TDP2PTPRCS100A4MEN1LMNA | |
| SCHEMBL1097849 | 0.84 | TDP2 (0.46) | TDP2PTPRCS100A4MEN1LMNA | |
| SCHEMBL31533407 | 0.81 | TDP2 (0.48) | TDP2PTPRCS100A4MEN1LMNA | |
| SCHEMBL15617589 | 0.77 | PNMT (0.53) | TDP2PTPRCS100A4MEN1LMNA | |
| SCHEMBL1811557 | 0.75 | PTPRC (0.45) | TDP2PTPRCS100A4MEN1LMNA | |
| SCHEMBL20500978 | 0.75 | PTPRC (0.45) | TDP2PTPRCS100A4MEN1LMNA | |
| SCHEMBL15617650 | 0.75 | TLR9 (0.46) | TDP2PTPRCS100A4MEN1LMNA | |
| SCHEMBL8555030 | 0.74 | METAP1 (0.54) | TDP2PTPRCS100A4TLR9TDP1 | |
| SCHEMBL11563863 | 0.73 | TSHR (0.39) | MEN1MAPTKMT2AALDH1A1CYP3A4 | |
| SCHEMBL6972986 | 0.73 | METAP1 (0.54) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-85101925-A | Prepare the method that salt is allowed in heterogeneous ring compound and pharmacy thereof | — | 1987-01-24 | — | — | CN | disclosed |
| US-4616013-A | INOTROPIC AND VASODILATOR ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-10-07 | — | — | US | disclosed |
| EP-0145236-A2 | Thiadiazinone compounds, process for their preparation, and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-06-19 | — | — | EP | disclosed |