Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17091611 | 0.72 | MAPK1 (0.39) | MAPTNPSR1SMN1; SMN2MAPK1HTT | |
| SCHEMBL14337737 | 0.68 | NOTUM (0.38) | SMN1; SMN2ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL17224424 | 0.66 | MAPT (0.37) | MAPTNPSR1SMN1; SMN2MAPK1HTT | |
| SCHEMBL21590289 | 0.66 | HDAC1 (0.42) | MAPTNPSR1SMN1; SMN2MAPK1HTT | |
| SCHEMBL878133 | 0.66 | SLC6A2 (0.53) | ALDH1A1 | |
| SCHEMBL8697847 | 0.65 | MAOA (0.34) | MAPTMAPK1KDM4EALDH1A1TSHR | |
| SCHEMBL6653610 | 0.63 | — | — | |
| SCHEMBL1975101 | 0.61 | LMNA (0.50) | MAPTSMN1; SMN2MAPK1TSHR | |
| SCHEMBL8811436 | 0.61 | MAPT (0.41) | MAPTNPSR1SMN1; SMN2MAPK1HTT | |
| SCHEMBL30797260 | 0.60 | BPTF (0.37) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4602024-A | Substituted trifluoromethylphenyltetrahydropyridines having a cyano substituent and an anorectic activity, a process for preparing same and pharmaceutical compositions | SANOFI (FR) | 1986-07-22 | — | — | US | claimed |
| US-4472408-A | Substituted trifluoromethylphenyltetrahydropyridines having an anorectic activity | SANOFI (FR) | 1984-09-18 | — | — | US | claimed |