⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290577 | 0.73 | SLC18A3 (0.36) | — | |
| SCHEMBL18889654 | 0.71 | CHRNB2 (0.38) | — | |
| SCHEMBL7492955 | 0.65 | CYP2D6 (0.36) | — | |
| SCHEMBL10909473 | 0.63 | MAPT (0.35) | — | |
| SCHEMBL21590289 | 0.61 | HDAC1 (0.42) | — | |
| Hydrochloric Acid SCHEMBL17224424 | 0.61 | MAPT (0.37) | — | |
| SCHEMBL5352313 | 0.61 | MAPT (0.42) | — | |
| SCHEMBL23680805 | 0.61 | MAPK1 (0.37) | — | |
| SCHEMBL12170156 | 0.60 | MAOA (0.41) | — | |
| SCHEMBL7755392 | 0.59 | MBTD1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369887-B1 | Use of trifluoromethyl phenyl-tetrahydropyridines in the manufacture of a medicament for the treatment of anxio-depressive disorders | SANOFI SA (FR) | 1995-06-21 | — | — | EP | claimed |
| EP-0412901-B1 | USE OF TRIFLUOROMETHYL-PHENYLTETRAHYDROPYRIDINES FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF INTESTINAL MOTILITY | ELF SANOFI (FR) | 1993-05-05 | — | — | EP | claimed |
| US-5026716-A | Method of treatment of anxiety and anxio-depressive disorders | SANOFI (FR) | 1991-06-25 | — | — | US | claimed |
| EP-0412901-A2 | Use of trifluoromethyl-phenyltetrahydropyridines for the manufacture of medicaments for the treatment of intestinal motility | ELF SANOFI (FR) | 1991-02-13 | — | — | EP | claimed |
| EP-0369887-A2 | Use of trifluoromethyl phenyl-tetrahydropyridines in the manufacture of a medicament for the treatment of anxio-depressive disorders | SANOFI (FR) | 1990-05-23 | — | — | EP | claimed |
| JP-2256663-A | — | — | None | — | — | JP | disclosed |
| JP-3077824-A | — | — | None | — | — | JP | disclosed |
| JP-4226959-A | — | — | None | — | — | JP | disclosed |
| EP-0979079-B1 | USE OF TETRAHYDROPYRIDINE DERIVATIVES TO PREPARE MEDICINES FOR TREATING DISEASES CAUSING DEMYELINATION | SANOFI SYNTHELABO (FR) | 2004-06-16 | — | — | EP | disclosed |
| US-6344464-B1 | Use of tetrahydropyridine derivatives to prepare medicines for treating diseases causing demyelination | SANOFI-SYNTHELABO (FR) | 2002-02-05 | — | — | US | disclosed |
| EP-0950049-B1 | DIPHENYL ALKYL-TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI SYNTHELABO (FR) | 2001-10-17 | — | — | EP | disclosed |
| EP-0979079-A1 | USE OF TETRAHYDROPYRIDINE DERIVATIVES TO PREPARE MEDICINES FOR TREATING DISEASES CAUSING DEMYELINATION | SANOFI-SYNTHELABO (FR) | 2000-02-16 | — | — | EP | disclosed |
| EP-0369887-A2 | Use of trifluoromethyl phenyl-tetrahydropyridines in the manufacture of a medicament for the treatment of anxio-depressive disorders | SANOFI (FR) | 1990-05-23 | — | — | EP | disclosed |
| US-4602024-A | Substituted trifluoromethylphenyltetrahydropyridines having a cyano substituent and an anorectic activity, a process for preparing same and pharmaceutical compositions | SANOFI (FR) | 1986-07-22 | — | — | US | disclosed |
| EP-0101381-B1 | ANOREXIC TRIFLUOROMETHYL PHENYL TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1985-12-04 | — | — | EP | disclosed |
| US-4521428-A | Anorexigenic trifluoromethylphenyltetrahydropyridines and pharmaceutical compositions containing them | SANOFI (FR) | 1985-06-04 | — | — | US | disclosed |
| EP-0060176-B1 | SUBSTITUTED TRIFLUOROMETHYLPHENYLTETRAHYDROPYRIDINES HAVING ANORECTIC ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI S.A. (FR) | 1985-01-02 | — | — | EP | disclosed |
| US-4472408-A | Substituted trifluoromethylphenyltetrahydropyridines having an anorectic activity | SANOFI (FR) | 1984-09-18 | — | — | US | disclosed |
| EP-0101381-A1 | Anorexic trifluoromethyl phenyl tetrahydropyridines, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1984-02-22 | — | — | EP | disclosed |
| EP-0060176-A1 | Substituted trifluoromethylphenyltetrahydropyridines having anorectic activity, their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1982-09-15 | — | — | EP | disclosed |