Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | POLQ | O75417 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.38 |
| ▸ | GPX4 | P36969 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1802310 | 0.98 | TP53 (0.45) | TP53MAPTHPGDTDP1SLC6A2 | |
| SCHEMBL9446178 | 0.85 | ALDH1A1 (0.43) | TP53MAPTHPGDTDP1SLC6A2 | |
| SCHEMBL17101217 | 0.84 | MAPT (0.41) | TP53MAPTHPGDTDP1SLC6A2 | |
| SCHEMBL11321199 | 0.83 | TP53 (0.44) | TP53MAPTHPGDTDP1SLC6A2 | |
| SCHEMBL11785353 | 0.82 | TP53 (0.47) | TP53MAPTHPGDTDP1SLC6A2 | |
| SCHEMBL8394324 | 0.81 | TP53 (0.45) | TP53MAPTHPGDTDP1SLC6A2 | |
| SCHEMBL2405543 | 0.81 | TP53 (0.45) | TP53MAPTHPGDTDP1THRB | |
| SCHEMBL9001023 | 0.81 | TP53 (0.45) | TP53MAPTHPGDTDP1SLC6A2 | |
| SCHEMBL11748273 | 0.80 | TP53 (0.42) | TP53MAPTHPGDTDP1SLC6A2 | |
| SCHEMBL11786816 | 0.80 | GPX4 (0.54) | TP53MAPTSLC6A2SLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4605615-A | CULTURING STREPTOMYCES | TOYO JOZO KABUSHIKI KAISHA (JP) | 1986-08-12 | — | — | US | disclosed |