Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23782830 | 0.78 | HTR2A (0.38) | PGRMALT1POLBHTR2AHTR2C | |
| SCHEMBL10909721 | 0.77 | METAP1 (0.42) | PGRMAOBBACE1 | |
| SCHEMBL10908106 | 0.76 | CA1 (0.41) | PGRMALT1 | |
| SCHEMBL6251847 | 0.76 | METAP1 (0.41) | PGRHTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL9588878 | 0.75 | CYP11B2 (0.47) | PGRMALT1HTR2AHTR2CHTR2B | |
| SCHEMBL10341528 | 0.75 | PGR (0.36) | PGRMALT1POLBHTR2AHTR2C | |
| SCHEMBL10341501 | 0.75 | DGAT1 (0.42) | PGRMALT1POLBMAOBALK | |
| SCHEMBL10908361 | 0.72 | SRD5A2 (0.46) | POLB | |
| SCHEMBL1573061 | 0.71 | PGR (0.46) | PGRMALT1POLBHTR2AHTR2C | |
| SCHEMBL10341526 | 0.71 | PGR (0.36) | PGRMALT1POLBHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4616013-A | INOTROPIC AND VASODILATOR ACTIVITY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-10-07 | — | — | US | disclosed |
| EP-0145236-A2 | Thiadiazinone compounds, process for their preparation, and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-06-19 | — | — | EP | disclosed |