Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 6/20 | 0.63 |
| ▸ | PGR | P06401 | 8/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.63 |
| ▸ | AR | P10275 | 3/20 | 0.63 |
| ▸ | F2 | P00734 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | USP2 | O75604 | 3/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10906135 | 1.00 | NR3C1 (0.63) | NR3C1PGRCYP3A4ARF2 | |
| SCHEMBL10900414 | 0.97 | NR3C1 (0.63) | NR3C1PGRCYP3A4ARF2 | |
| SCHEMBL10900405 | 0.97 | NR3C1 (0.63) | NR3C1PGRCYP3A4ARF2 | |
| SCHEMBL10900439 | 0.96 | PGR (0.66) | NR3C1PGRCYP3A4ARF2 | |
| SCHEMBL10900446 | 0.96 | PGR (0.66) | NR3C1PGRCYP3A4ARF2 | |
| SCHEMBL10910515 | 0.95 | PGR (0.67) | NR3C1PGRCYP3A4ARF2 | |
| SCHEMBL10910516 | 0.95 | PGR (0.67) | NR3C1PGRCYP3A4ARF2 | |
| SCHEMBL10903136 | 0.94 | NR3C1 (0.66) | NR3C1PGRCYP3A4ARF2 | |
| SCHEMBL10903142 | 0.94 | NR3C1 (0.66) | NR3C1PGRCYP3A4ARF2 | |
| SCHEMBL13653812 | 0.94 | PGR (0.62) | NR3C1PGRCYP3A4ARF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0072546-B1 | HYDROCORTISONE DERIVATIVES, THEIR PREPARATION AND THEIR UTILIZATION | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-10-09 | — | — | EP | claimed |
| US-4435390-A | Hydrocortisone derivatives, the preparation and use thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-03-06 | — | — | US | claimed |
| EP-0072546-A1 | Hydrocortisone derivatives, their preparation and their utilization | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-02-23 | — | — | EP | claimed |
| US-4567172-A | ANTINFLAMMATORY AGENTS, ANTIALLERGENS | OHTA SEIYAKU KABUSHIKI KAISHA (JP) | 1986-01-28 | — | — | US | disclosed |
| EP-0072546-B1 | HYDROCORTISONE DERIVATIVES, THEIR PREPARATION AND THEIR UTILIZATION | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-10-09 | — | — | EP | disclosed |
| US-4435390-A | Hydrocortisone derivatives, the preparation and use thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-03-06 | — | — | US | disclosed |
| EP-0095894-A2 | 6 Alpha-methylprednisolone derivatives | OHTA SEIYAKU KABUSHIKI KAISHA. (JP) | 1983-12-07 | — | — | EP | disclosed |