SCHEMBL10914280

SCHEMBL10914280

CCCC(=O)OC1OC(=O)c2ccc(C(=O)c3ccc4c(c3)C(OC(=O)CCC)OC4=O)cc21

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.39
KDM4E B2RXH2 3/20 0.39
MEN1 O00255 2/20 0.39
ALDH1A1 P00352 2/20 0.39
GAA P10253 2/20 0.39
LMNA P02545 2/20 0.38
CYP1A1 P04798 1/20 0.37
POLB P06746 1/20 0.36
MTNR1B P49286 1/20 0.34
NPSR1 Q6W5P4 3/20 0.34
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
GLA P06280 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10920011 0.95 KMT2A (0.36) KMT2AKDM4EMEN1ALDH1A1GAA
SCHEMBL10918036 0.93 CYP1A1 (0.40) KMT2AKDM4EMEN1ALDH1A1GAA
SCHEMBL10919884 0.90 MTNR1B (0.37) KMT2AKDM4EMEN1ALDH1A1GAA
SCHEMBL10917131 0.90 KDM4E (0.41) KMT2AKDM4EMEN1ALDH1A1GAA
SCHEMBL10914249 0.88 CYP1A1 (0.38) KMT2AKDM4EMEN1ALDH1A1GAA
SCHEMBL7286996 0.85 POLB (0.45) KMT2AKDM4EMEN1ALDH1A1LMNA
SCHEMBL10917286 0.82 PRKCA (0.38) KMT2AMEN1ALDH1A1LMNACYP1A1
SCHEMBL10917903 0.82 TSHR (0.42) KMT2AKDM4EALDH1A1LMNACYP1A1
SCHEMBL10917276 0.82 KDM4E (0.43) KMT2AKDM4EMEN1ALDH1A1GAA
SCHEMBL10920814 0.79 ELANE (0.38) KMT2AKDM4EMEN1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4599445-A Process for benzophenone tetracarboxylic acid THE DOW CHEMICAL COMPANY (US) 1986-07-08 US disclosed
US-4562271-A Preparation of 3-alkanoyloxyphthalides THE UPJOHN COMPANY (US) 1985-12-31 US disclosed
US-4485247-A 3-Alkanoyloxyphthalides THE UPJOHN COMPANY (US) 1984-11-27 US disclosed
EP-0125342-A1 Process for preparation of aromatic polycarboxylic acids and intermediates therefor THE UPJOHN COMPANY (US) 1984-11-21 EP disclosed