Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.57 |
| ▸ | DRD3 | P35462 | 7/20 | 0.55 |
| ▸ | HTR1A | P08908 | 5/20 | 0.55 |
| ▸ | HTR2A | P28223 | 5/20 | 0.55 |
| ▸ | HRH1 | P35367 | 5/20 | 0.55 |
| ▸ | DRD4 | P21917 | 4/20 | 0.55 |
| ▸ | DRD1 | P21728 | 4/20 | 0.55 |
| ▸ | DRD5 | P21918 | 4/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.55 |
| ▸ | HTR7 | P34969 | 4/20 | 0.55 |
| ▸ | HTR2B | P41595 | 4/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10916751 | 0.99 | DRD2 (0.56) | DRD2DRD3HTR1AHTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL10914753 | 0.89 | DRD2 (0.54) | DRD2DRD3HTR1AHTR2AHRH1 | |
| SCHEMBL10970466 | 0.84 | CCR3 (0.56) | DRD2DRD3HTR1AHTR2ADRD4 | |
| Hydrochloric Acid SCHEMBL10918932 | 0.83 | OPRM1 (0.52) | DRD2DRD3DRD4OPRM1 | |
| Hydrochloric Acid SCHEMBL10920703 | 0.81 | OPRL1 (0.61) | DRD2DRD3DRD4ABCB11CHRM4 | |
| SCHEMBL10972939 | 0.79 | DRD2 (0.48) | DRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL10967545 | 0.78 | DRD2 (0.48) | DRD2DRD3DRD4OPRM1 | |
| SCHEMBL10916090 | 0.77 | DRD2 (0.50) | DRD2DRD3DRD4MEN1CYP2D6 | |
| Hydrochloric Acid SCHEMBL10917172 | 0.77 | SIGMAR1 (0.57) | DRD2PMP22SIGMAR1 | |
| Hydrochloric Acid SCHEMBL10919520 | 0.77 | OPRM1 (0.39) | DRD2DRD3HTR7OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064707-B1 | 4-(4-PHENYL-1-PIPERIDINYL)METHYL-5-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-07-23 | — | — | EP | claimed |
| EP-0064707-A1 | 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | claimed |
| US-4329471-A | CARDIOTONICS, HYPOTENSIVE AGENTS, AND ANTITHROMBOTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-05-11 | — | — | US | claimed |