Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10923146 | 0.81 | ATM (0.39) | ATML3MBTL1POLBTHRB | |
| SCHEMBL31168484 | 0.80 | GCK (0.36) | KDM4ENPC1TP53POLBNFKB1 | |
| SCHEMBL10920423 | 0.75 | SMN1; SMN2 (0.46) | ATML3MBTL1KDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL10925140 | 0.75 | ATM (0.35) | ATML3MBTL1 | |
| SCHEMBL24925495 | 0.71 | KDM4E (0.40) | KDM4ENPC1TP53POLBNFKB1 | |
| SCHEMBL15054566 | 0.71 | ALDH1A1 (0.42) | ATML3MBTL1KDM4ENPC1TP53 | |
| SCHEMBL9655955 | 0.71 | ATM (0.39) | ATML3MBTL1POLBTHRB | |
| SCHEMBL11090688 | 0.70 | ALDH1A1 (0.52) | ATML3MBTL1KDM4ENPC1RAB9A | |
| SCHEMBL31168612 | 0.67 | KDM4E (0.41) | ATMKDM4ESMN1; SMN2 | |
| SCHEMBL2614509 | 0.66 | KDM4E (0.39) | KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068834-B1 | PYRIMIDINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-09-03 | — | — | EP | disclosed |
| US-4535163-A | ANTIHISTAMINES; PYRIMIDONE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-08-13 | — | — | US | disclosed |
| US-4444772-A | 2-(3,5-DISUBSTITUTED-PYRIDYLALKYLAMINO)-5-PYRIDYLMETHYL-4 -PYRIMIDONE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-04-24 | — | — | US | disclosed |
| EP-0068834-A2 | Pyrimidinone derivatives and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-01-05 | — | — | EP | disclosed |