Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31168603 | 0.83 | AGBL2 (0.42) | KDM4EHSD17B10ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL31168685 | 0.83 | EGFR (0.48) | KDM4EVEGFAFLT1EGLN1EGLN3 | |
| SCHEMBL28801471 | 0.77 | AGBL2 (0.42) | KDM4EHSD17B10ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL31168468 | 0.76 | AKR1C3 (0.40) | KDM4EALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL125390 | 0.74 | KDM4E (0.40) | KDM4EHSD17B10ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL15054566 | 0.74 | ALDH1A1 (0.42) | KDM4EATMHSD17B10ALDH1A1HPGD | |
| SCHEMBL8825478 | 0.73 | ALDH1A1 (0.53) | KDM4EHSD17B10ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1915182 | 0.73 | ATM (0.41) | KDM4EATMVEGFAFLT1EGLN1 | |
| SCHEMBL31168484 | 0.71 | GCK (0.36) | KDM4ESMN1; SMN2MAPT | |
| SCHEMBL31168407 | 0.71 | EGFR (0.39) | KDM4EEGLN1HSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024216164-A1 | N2-((5-HYDROXY)-2-PYRIDYL)-PYRIDINE-2,4-DIAMINE DERIVATIVES AS EHMT1/2 MODULATORS FOR THE TREATMENT OF CANCER | TANGO THERAPEUTICS, INC. (US) | 2024-10-17 | — | — | WO | disclosed |