Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TKT | P29401 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | SELL | P14151 | 1/20 | 0.32 |
| ▸ | SELP | P16109 | 1/20 | 0.32 |
| ▸ | SELE | P16581 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15054566 | 0.80 | ALDH1A1 (0.42) | KDM4ENPC1TP53POLBNFKB1 | |
| SCHEMBL10918083 | 0.80 | ATM (0.39) | KDM4ENPC1TP53POLBNFKB1 | |
| SCHEMBL31168519 | 0.78 | S100A9 (0.38) | MAPK1KCNJ5KCNJ3 | |
| SCHEMBL31168516 | 0.78 | S100A9 (0.38) | MAPK1KCNJ5KCNJ3 | |
| SCHEMBL31168640 | 0.78 | AGBL2 (0.38) | KCNJ5KCNJ3 | |
| SCHEMBL24925495 | 0.76 | KDM4E (0.40) | KDM4ENPC1TP53POLBNFKB1 | |
| SCHEMBL4277341 | 0.73 | TKT (0.48) | GCKTKTHCAR2TNKS2NOS3 | |
| SCHEMBL31168612 | 0.71 | KDM4E (0.41) | KDM4ESMN1; SMN2MAPT | |
| SCHEMBL8664688 | 0.70 | MAPT (0.35) | KDM4EPOLBMAPK1CCR1CCR5 | |
| SCHEMBL6369030 | 0.68 | NOS3 (0.41) | KDM4ETP53SMN1; SMN2TKTCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024216164-A1 | N2-((5-HYDROXY)-2-PYRIDYL)-PYRIDINE-2,4-DIAMINE DERIVATIVES AS EHMT1/2 MODULATORS FOR THE TREATMENT OF CANCER | TANGO THERAPEUTICS, INC. (US) | 2024-10-17 | — | — | WO | disclosed |