Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10921216 | 0.85 | CYP1A2 (0.43) | POLBALDH1A1 | |
| SCHEMBL14725062 | 0.71 | BRAF (0.48) | POLBATMAPOBEC3GALDH1A1MTOR | |
| SCHEMBL11533616 | 0.71 | KMT2A (0.43) | POLBALDH1A1MAPT | |
| SCHEMBL2863120 | 0.70 | NR4A1 (0.44) | POLBATMAPOBEC3GALDH1A1NR4A1 | |
| SCHEMBL2305294 | 0.69 | ESR1 (0.48) | POLBALDH1A1PDE5A | |
| SCHEMBL11450381 | 0.68 | ADORA2A (0.36) | POLBALDH1A1RAB9A | |
| SCHEMBL15215745 | 0.66 | ALDH1A1 (0.52) | POLBALDH1A1RAB9AMAPTPDE1B | |
| SCHEMBL10768056 | 0.66 | KDM4E (0.40) | ALDH1A1NR4A1NR4A2 | |
| SCHEMBL11387701 | 0.65 | NR4A1 (0.67) | POLBALDH1A1NR4A1NR4A2RAB9A | |
| SCHEMBL15015960 | 0.64 | P2RX3 (0.47) | POLBATMAPOBEC3GALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107914-B1 | AMINOPYRIMIDINONE DERIVATIVES USEFUL AS HISTAMINE H1-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-05-14 | — | — | EP | disclosed |
| US-4537891-A | 2-(3,5-Substituted-2-pyridylalkylamino)-5-benzyl-4-pyrimidones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-08-27 | — | — | US | disclosed |
| EP-0107914-A1 | Aminopyrimidinone derivatives useful as histamine H1-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-05-09 | — | — | EP | disclosed |