Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 4/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.46 |
| ▸ | ASAH1 | Q13510 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10919746 | 0.78 | DNMT3A (0.52) | ADRB2ADRB1ADRB3SMN1; SMN2LMNA | |
| SCHEMBL10979942 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNASTAT6DNMT3AASAH1 | |
| SCHEMBL28377896 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNASTAT6DNMT3AASAH1 | |
| SCHEMBL29585279 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNASTAT6DNMT3AASAH1 | |
| SCHEMBL11443588 | 0.70 | KMT2A (0.60) | SMN1; SMN2LMNASTAT6DNMT3AASAH1 | |
| SCHEMBL250113 | 0.70 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNASTAT6DNMT3AASAH1 | |
| SCHEMBL250172 | 0.70 | HTT (0.66) | SMN1; SMN2LMNASTAT6DNMT3AASAH1 | |
| SCHEMBL5348211 | 0.69 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNASTAT6DNMT3AASAH1 | |
| SCHEMBL29833600 | 0.68 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNASTAT6DNMT3AASAH1 | |
| SCHEMBL857765 | 0.68 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNASTAT6DNMT3AASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0066144-B1 | BENZYLAZOLE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1986-02-19 | — | — | EP | disclosed |
| US-4430331-A | Antiarrhytmic benzylimidazole | SHIONOGI & CO., LTD. (JP) | 1984-02-07 | — | — | US | disclosed |
| EP-0066144-A2 | Benzylazole derivatives | SHIONOGI & CO., LTD. (JP) | 1982-12-08 | — | — | EP | disclosed |