SCHEMBL10920643

SCHEMBL10920643

C=CCCSc1ccc(C)cc1

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
ALDH1A1 P00352 6/20 0.44
MAPT P10636 2/20 0.44
MAPK1 P28482 1/20 0.42
HPGD P15428 8/20 0.41
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
DRD2 P14416 1/20 0.38
DRD4 P21917 1/20 0.38
POLB P06746 1/20 0.38
TSHR P16473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20692333 0.83 MAPK1 (0.37) ALDH1A1MAPK1CYP3A4TSHR
SCHEMBL5168911 0.79 NPC1 (0.65) NPC1RAB9AALDH1A1MAPTMAPK1
SCHEMBL18560248 0.79 NPC1 (0.47) NPC1RAB9AALDH1A1MAPTMAPK1
SCHEMBL7514361 0.79 ALDH1A1 (0.49) NPC1RAB9AALDH1A1MAPTMAPK1
SCHEMBL28167886 0.79 KDM4E (0.46) NPC1RAB9AALDH1A1MAPTHPGD
SCHEMBL10516600 0.78 NPC1 (0.41) NPC1RAB9AALDH1A1MAPTMAPK1
SCHEMBL10739081 0.78 ALDH1A1 (0.61) NPC1RAB9AALDH1A1MAPTMAPK1
SCHEMBL1740016 0.76 NPC1 (0.52) NPC1RAB9AALDH1A1MAPTMAPK1
SCHEMBL5172043 0.75 POLB (0.56) NPC1RAB9AALDH1A1MAPTHPGD
SCHEMBL9808095 0.75 NPC1 (0.55) NPC1RAB9AALDH1A1MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115724706-B Method for rapidly converting aldehyde group into cyano group 中国科学院兰州化学物理研究所 2024-04-12 CN disclosed
US-4584144-A Monomeric thioloesterification of 1,3-alkadiene CELANESE CORPORATION (US) 1986-04-22 US disclosed