Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364446 | 0.98 | AKR1B1 (0.95) | AKR1B1KMT2AADRA2AADRA1AMEN1 | |
| Hydrochloric Acid SCHEMBL1374156 | 0.98 | AKR1B1 (0.95) | AKR1B1KMT2AADRA2AADRA1AMEN1 | |
| SCHEMBL11691926 | 0.87 | AKR1B1 (0.77) | AKR1B1KMT2AADRA2AADRA1AMEN1 | |
| SCHEMBL29570152 | 0.86 | AKR1B1 (0.74) | AKR1B1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL29933615 | 0.86 | AKR1B1 (0.74) | AKR1B1KMT2AADRA2AADRA1AMEN1 | |
| SCHEMBL13829757 | 0.86 | AKR1B1 (0.74) | AKR1B1KMT2AADRA2AADRA1AMEN1 | |
| SCHEMBL1285811 | 0.86 | AKR1B1 (0.74) | AKR1B1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL3044981 | 0.86 | AKR1B1 (0.74) | AKR1B1KMT2AADRA2AADRA1AMEN1 | |
| SCHEMBL17410055 | 0.86 | AKR1B1 (0.74) | AKR1B1KMT2AADRA2AADRA1AMEN1 | |
| SCHEMBL1626950 | 0.86 | AKR1B1 (0.74) | AKR1B1KMT2AADRA2AADRA1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 599 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12454512-B2 | Processes and intermediates for the preparation of 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl]ethenone | ELI LILLY AND COMPANY (US) | 2025-10-28 | — | — | US | claimed |
| CN-113993849-B | Process and intermediates for preparing 2- (2, 6-dichlorophenyl) -1- [ (1S, 3R) -3- (hydroxymethyl) -5- (3-hydroxy-3-methylbutyl) -1-methyl-3, 4-dihydroisoquinolin-2 (1H) -yl ] ketene | 伊莱利利公司 | 2025-03-07 | — | — | CN | claimed |
| CN-114994196-B | High performance liquid chromatography separation method for guanfacine hydrochloride intermediate 2, 6-dichlorophenylacetic acid and impurities | 上海应用技术大学 | 2024-12-31 | — | — | CN | claimed |
| EP-3986867-B1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 2-(2,6-DICHLOROPHENYL)-1-[(1S,3R)-3-(HYDROXYMETHYL)-5-(3-HYDROXY-3-METHYLBUTYL)-1-METHYL-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]ETHENONE | LILLY CO ELI (US) | 2023-09-13 | — | — | EP | claimed |
| CN-115028554-B | Guanfacine hydrochloride and preparation method thereof | 海南慧谷药业有限公司 | 2023-04-28 | — | — | CN | claimed |
| CN-115028554-A | Guanfacine hydrochloride and preparation method thereof | 广东科泰鼎润药业科技有限公司 | 2022-09-09 | — | — | CN | claimed |
| CN-114994196-A | High performance liquid chromatography separation method for guanfacine hydrochloride intermediate 2,6-dichlorophenylacetic acid and impurities | 上海应用技术大学 | 2022-09-02 | — | — | CN | claimed |
| US-20220242826-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 2-(2,6-DICHLOROPHENYL)-1-[(1S,3R)-3-(HYDROXYMETHYL)-5-(3-HYDROXY-3-METHYLBUTYL)-1-METHYL-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]ETHENONE | ELI LILLY AND COMPANY | 2022-08-04 | — | — | US | claimed |
| CN-114409524-A | Preparation method of 2, 6-dichlorophenylacetic acid | 上海柏狮生物科技有限公司 | 2022-04-29 | — | — | CN | claimed |
| EP-3986867-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 2-(2,6-DICHLOROPHENYL)-1-[(1S,3R)-3-(HYDROXYMETHYL)-5-(3-HYDROXY-3-METHYLBUTYL)-1-METHYL-3,4-DIHYDROISOQUINOLIN-2(1)-YL]ETHENONE | ELI LILLY AND COMPANY (US) | 2022-04-27 | — | — | EP | claimed |
| US-5712307-A | Methods of inducing the production of hemoglobin and treating pathologies associated with abnormal hemoglobin activity using phemylacetic acids and derivatives therof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-01-27 | — | — | US | claimed |
| US-5710178-A | ARYL- AND ARYLOXYALKANOIC ACIDS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-01-20 | — | — | US | claimed |
| US-5708025-A | BY INDUCING PRODUCTION OF FETAL HEMOGLOBINS BY ADMINISTERING SPECIFIED ARYL ACIDS, DERIVATIVES, SALTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-01-13 | — | — | US | claimed |
| US-5679799-A | Method for producing oxyindoles | K-I CHEMICAL INDUSTRY CO., LTD. (JP) | 1997-10-21 | — | — | US | claimed |
| US-5661179-A | ADMINISTERING; TREATS NEUROBLASTOMA, MYELODYSPLASIA, NON-SMALL CELL LUNG CANCER, PROSTATE CANCER, MELANOMA, BRAIN TUMOR, KAPOSI'S SARCOMA, LYMPHOMA, LEUKEMIA, BREAST AND LUNG CANCER, OSTEOSARCOMA AND FIBROSARCOMA | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1997-08-26 | — | — | US | claimed |
| US-5654333-A | THERAPY FOR ANEMIA, CANCER, AIDS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1997-08-05 | — | — | US | claimed |
| US-5635532-A | ADMINISTERING PHENYL OR NAPHTHYL ACETIC ACID DERIVATIVES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1997-06-03 | — | — | US | claimed |
| US-5635533-A | ANTITUMOR AGENTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1997-06-03 | — | — | US | claimed |
| US-5605930-A | ADMINISTERING PHENYLACETIC ACID AS AN INHIBITOR OF THE MEVALONATE PATHWAY | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1997-02-25 | — | — | US | claimed |
| EP-0710648-A1 | Method for producing oxyindoles | K I CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-05-08 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12454512-B2 | Processes and intermediates for the preparation of 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl]ethenone | PAM, TLR1, TLR2 | AKR1B1 953/4885KMT2A 1763/4885ADRA2A 455/4885 |
| US-20220242826-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 2-(2,6-DICHLOROPHENYL)-1-[(1S,3R)-3-(HYDROXYMETHYL)-5-(3-HYDROXY-3-METHYLBUTYL)-1-METHYL-3,4-DIHYDROISOQUINOLIN-2(1H)-YL]ETHENONE | PAM, TLR1, TLR2 | AKR1B1 953/4885KMT2A 1763/4885ADRA2A 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.