SCHEMBL10922604

SCHEMBL10922604

[CH2]C(CC)Nc1ccc(C(F)(F)F)cc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.44
ALDH1A1 P00352 1/20 0.44
PDE2A O00408 4/20 0.43
NPSR1 Q6W5P4 2/20 0.41
LMNA P02545 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
TP53 P04637 1/20 0.40
POLB P06746 1/20 0.40
GAA P10253 1/20 0.40
TSHR P16473 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA9 Q16790 1/20 0.37
ACHE P22303 1/20 0.37
KIF11 P52732 1/20 0.37
L3MBTL1 Q9Y468 2/20 0.36
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12871463 0.81 PDE2A (0.45) MAPTALDH1A1PDE2ANPSR1LMNA
SCHEMBL10848846 0.80 PDE2A (0.47) MAPTALDH1A1PDE2ANPSR1LMNA
SCHEMBL24106554 0.79 PDE2A (0.53) MAPTALDH1A1PDE2ANPSR1LMNA
SCHEMBL14996620 0.76 PDE2A (0.50) MAPTALDH1A1PDE2ANPSR1LMNA
SCHEMBL12856309 0.76 PDE2A (0.50) MAPTALDH1A1PDE2ANPSR1LMNA
SCHEMBL10931606 0.76 PDE2A (0.46) MAPTALDH1A1PDE2ANPSR1LMNA
SCHEMBL12856451 0.74 PDE2A (0.47) MAPTALDH1A1PDE2ANPSR1LMNA
SCHEMBL12859563 0.74 PDE2A (0.47) MAPTALDH1A1PDE2ANPSR1LMNA
SCHEMBL1768902 0.73 ALDH1A1 (0.54) MAPTALDH1A1PDE2AMEN1KMT2A
SCHEMBL10954628 0.73 PDE2A (0.46) MAPTALDH1A1PDE2ANPSR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0049977-B1 INSECTICIDAL (1,1'-BIPHENYL)-3-YLMETHYL ESTERS, THEIR PRODUCTION AND USE AND COMPOSITIONS CONTAINING THEM FMC Corporation (US) 1986-02-26 EP claimed
EP-0143152-A2 Insecticidal (1,1'-biphenyl)-3-ylmethyl esters, their production and use and compositions containing them FMC Corporation (US) 1985-06-05 EP claimed
EP-0049977-A1 Insecticidal (1,1'-biphenyl)-3-ylmethyl esters, their production and use and compositions containing them FMC Corporation (US) 1982-04-21 EP claimed
EP-0049977-B1 INSECTICIDAL (1,1'-BIPHENYL)-3-YLMETHYL ESTERS, THEIR PRODUCTION AND USE AND COMPOSITIONS CONTAINING THEM FMC Corporation (US) 1986-02-26 EP disclosed
EP-0143152-A3 INSECTICIDAL (1,1'-BIPHENYL)-3-YLMETHYL ESTERS, THEIR PRODUCTION AND USE AND COMPOSITIONS CONTAINING THEM FMC Corporation (US) 1985-07-17 EP disclosed
EP-0143153-A2 Insecticidal 1,1'-Biphenyl -3-ylmethyl esters, their production and use and compositions containing them FMC Corporation (US) 1985-06-05 EP disclosed
EP-0143152-A2 Insecticidal (1,1'-biphenyl)-3-ylmethyl esters, their production and use and compositions containing them FMC Corporation (US) 1985-06-05 EP disclosed
EP-0143152-A2 Insecticidal (1,1'-biphenyl)-3-ylmethyl esters, their production and use and compositions containing them FMC Corporation (US) 1985-06-05 EP disclosed
US-4402973-A Insecticidal (1,1'-biphenyl)-3-ylmethyl esters FMC CORPORATION (US) 1983-09-06 US disclosed
EP-0049977-A1 Insecticidal (1,1'-biphenyl)-3-ylmethyl esters, their production and use and compositions containing them FMC Corporation (US) 1982-04-21 EP disclosed