Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | GGT1 | P19440 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6026854 | 0.83 | TP53 (0.58) | TP53HTTFOLH1KDM4EALDH1A1 | |
| SCHEMBL11879636 | 0.81 | KDM4E (0.64) | HTTKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL31169318 | 0.80 | KDM4E (0.68) | TP53HTTFOLH1KDM4EALDH1A1 | |
| SCHEMBL31482063 | 0.80 | HTT (0.64) | TP53HTTFOLH1KDM4EALDH1A1 | |
| SCHEMBL23363642 | 0.79 | RXRA (0.56) | FOLH1KDM4EALDH1A1HPGDPTGER1 | |
| SCHEMBL30495975 | 0.79 | RXRA (0.56) | FOLH1KDM4EALDH1A1HPGDPTGER1 | |
| SCHEMBL11094896 | 0.75 | PPARG (0.47) | KDM4EALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL11618784 | 0.75 | NR4A2 (0.53) | TP53HTTFOLH1KDM4EALDH1A1 | |
| SCHEMBL24677801 | 0.74 | HTT (0.50) | TP53HTTFOLH1ALDH1A1CYP2C9 | |
| SCHEMBL29831705 | 0.74 | MRGPRX4 (0.51) | TP53HTTFOLH1ALDH1A1MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0054924-B1 | PHARMACEUTICAL COMPOUNDS, THEIR PREPARATION AND USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-08-06 | — | — | EP | disclosed |
| US-4535183-A | PALLIATION OF SICKLE CELL ANEMIA, RESPIRATORY DISORDERS, HYPOXIA, RADIOSENSITIZATION OF TUMORS | BURROUGHS WELLCOME CO. (US) | 1985-08-13 | — | — | US | disclosed |
| EP-0054924-A2 | Pharmaceutical compounds, their preparation and use | THE WELLCOME FOUNDATION LIMITED (GB) | 1982-06-30 | — | — | EP | disclosed |