Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 9/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30558899 | 1.00 | HTT (0.50) | HTTTP53MRGPRX4FOLH1CYP2C9 | |
| SCHEMBL24677759 | 0.89 | MRGPRX4 (0.47) | HTTMRGPRX4CYP2C9HIF1ANPC1 | |
| SCHEMBL24677896 | 0.88 | MRGPRX4 (0.51) | HTTTP53MRGPRX4FOLH1ALDH1A1 | |
| SCHEMBL29831705 | 0.88 | MRGPRX4 (0.51) | HTTTP53MRGPRX4FOLH1ALDH1A1 | |
| SCHEMBL25950573 | 0.87 | ALDH1A1 (0.42) | HTTTP53MRGPRX4CYP2C9HIF1A | |
| SCHEMBL31456044 | 0.80 | ERN1 (0.54) | HTTMRGPRX4NPC1RAB9AALDH1A1 | |
| SCHEMBL24677760 | 0.79 | MRGPRX4 (0.46) | HTTMRGPRX4CYP2C9NPSR1ALDH1A1 | |
| SCHEMBL30447357 | 0.79 | MRGPRX4 (0.46) | HTTMRGPRX4CYP2C9NPSR1ALDH1A1 | |
| SCHEMBL24677758 | 0.79 | MRGPRX4 (0.46) | HTTTP53MRGPRX4CYP2C9ALDH1A1 | |
| SCHEMBL26507030 | 0.76 | LMNA (0.39) | HTTCYP2C9NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4314004-B1 | CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | LILLY CO ELI (US) | 2025-01-22 | — | — | EP | disclosed |
| US-12162905-B2 | Carboxy substituted glucocorticoid receptor agonists | ELI LILLY AND COMPANY (US) | 2024-12-10 | — | — | US | disclosed |
| EP-4314004-A1 | CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | Eli Lilly and Company (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-116888137-A | Carboxy substituted glucocorticoid receptor agonists | 伊莱利利公司 | 2023-10-13 | — | — | CN | disclosed |
| US-20230227493-A1 | CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | ELI LILLY AND COMPANY | 2023-07-20 | — | — | US | disclosed |
| WO-2022204099-A1 | CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2022-09-29 | — | — | WO | disclosed |
| US-20220306681-A1 | CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | ELI LILLY AND COMPANY | 2022-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227493-A1 | CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | NR3C1, MC2R, NR3C2 | HTT 4334/4885TP53 2988/4885MRGPRX4 28/4885 |
| US-20220306681-A1 | CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | NR3C1, MC2R, NR3C2 | HTT 4334/4885TP53 2988/4885MRGPRX4 28/4885 |
| US-12162905-B2 | Carboxy substituted glucocorticoid receptor agonists | NR3C1, MC2R, NR3C2 | HTT 4334/4885TP53 2988/4885MRGPRX4 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.