Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | ERN1 | O75460 | 7/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4357334 | 0.86 | TDP1 (0.70) | TDP1ERN1PTPN1HSD17B10XDH | |
| Water SCHEMBL28578537 | 0.84 | TDP1 (0.67) | TDP1ERN1PTPN1HSD17B10XDH | |
| SCHEMBL19521160 | 0.78 | TDP1 (0.59) | TDP1ERN1PTPN1HSD17B10XDH | |
| SCHEMBL789811 | 0.76 | ERN1 (0.57) | TDP1ERN1PTPN1HSD17B10XDH | |
| SCHEMBL29889164 | 0.75 | TDP1 (1.00) | TDP1ERN1HSD17B10ALDH1A1MAPT | |
| SCHEMBL42560 | 0.75 | TDP1 (0.67) | TDP1ERN1PTPN1HSD17B10XDH | |
| SCHEMBL95435 | 0.75 | TDP1 (1.00) | TDP1ERN1HSD17B10ALDH1A1MAPT | |
| Bromide SCHEMBL29952083 | 0.74 | ERN1 (0.55) | TDP1ERN1PTPN1HSD17B10XDH | |
| SCHEMBL19521144 | 0.74 | TDP1 (0.59) | TDP1ERN1PTPN1HSD17B10XDH | |
| Hydrochloric Acid SCHEMBL29956054 | 0.74 | ERN1 (0.55) | TDP1ERN1PTPN1HSD17B10XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112620-B1 | 5-(SUBSTITUTED PHENYL) HYDANTOINS | PFIZER INC. (US) | 1986-12-30 | — | — | EP | disclosed |
| EP-0112620-A1 | 5-(Substituted phenyl) hydantoins | PFIZER INC. (US) | 1984-07-04 | — | — | EP | disclosed |
| US-4452806-A | Treating diabetic complications with 5-(substituted phenyl)hydantoins | PFIZER INC. (US) | 1984-06-05 | — | — | US | disclosed |