Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | MET | P08581 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.53 |
| ▸ | CDK8 | P49336 | 2/20 | 0.53 |
| ▸ | GSK3A | P49840 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | CDK7 | P50613 | 2/20 | 0.53 |
| ▸ | CDK9 | P50750 | 2/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10924899 | 0.89 | JAK2 (0.55) | JAK2NTRK1LCKCSF1RRET | |
| SCHEMBL11172982 | 0.84 | HAVCR2 (0.60) | JAK2NTRK1LCKCSF1RRET | |
| SCHEMBL8376738 | 0.84 | JAK2 (0.49) | JAK2NTRK1LCKCSF1RRET | |
| SCHEMBL11090747 | 0.84 | ADORA3 (0.67) | JAK2NTRK1LCKCSF1RRET | |
| SCHEMBL10927264 | 0.83 | JAK2 (0.40) | JAK2NTRK1LCKCSF1RRET | |
| SCHEMBL11175061 | 0.82 | JAK2 (0.48) | JAK2NTRK1LCKCSF1RRET | |
| SCHEMBL11173600 | 0.79 | JAK2 (0.45) | JAK2NTRK1LCKCSF1RRET | |
| SCHEMBL10924573 | 0.79 | LMNA (0.49) | MAPK8ADORA3 | |
| SCHEMBL11173744 | 0.78 | JAK2 (0.44) | JAK2NTRK1LCKCSF1RRET | |
| SCHEMBL404548 | 0.78 | HAVCR2 (0.80) | JAK2NTRK1LCKCSF1RRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080176-B1 | TRIAZOLOQUINAZOLINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1986-02-19 | — | — | EP | disclosed |