Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.67 |
| ▸ | CA2 | P00918 | 6/20 | 0.67 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.67 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.67 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.67 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.67 |
| ▸ | PARP1 | P09874 | 1/20 | 0.67 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.67 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.67 |
| ▸ | CES2 | O00748 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | PTGIR | P43119 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29008518 | 0.88 | CA1 (0.59) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL6206456 | 0.81 | CA1 (0.62) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL1839900 | 0.81 | CA1 (0.52) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL1839897 | 0.81 | CA1 (0.52) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL201860 | 0.80 | CA1 (0.61) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL428892 | 0.80 | PRSS1 (1.00) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL19529679 | 0.80 | CA1 (0.61) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL201761 | 0.80 | PARP10 (1.00) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL1837473 | 0.80 | CA1 (0.50) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL1837474 | 0.80 | CA1 (0.50) | CA1CA2PARP10PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0045081-B1 | TRISUBSTITUTED IMIDAZOLE DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE | CIBA-GEIGY AG (CH) | 1986-01-08 | — | — | EP | disclosed |
| US-4447431-A | VIRICIDES, ANTIINFLAMMATORY AND SUNCREEN AGENT | CIBA-GEIGY CORPORATION (US) | 1984-05-08 | — | — | US | disclosed |
| EP-0046451-A2 | Diaryl-imidazole compounds, methods for their preparation, pharmaceutical drugs containing them and their use | CIBA-GEIGY AG (CH) | 1982-02-24 | — | — | EP | disclosed |
| EP-0045081-A2 | Trisubstituted imidazole derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use | CIBA-GEIGY AG (CH) | 1982-02-03 | — | — | EP | disclosed |