SCHEMBL428892

SCHEMBL428892

COc1ccc(C(=N)N)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PRSS1 P07477 7/20 1.00
PRSS2 P07478 3/20 1.00
PRSS3 P35030 3/20 1.00
PTGIR P43119 1/20 0.78
NQO2 P16083 2/20 0.70
ST14 Q9Y5Y6 3/20 0.67
F2 P00734 2/20 0.67
PLAU P00749 2/20 0.67
CA1 P00915 1/20 0.61
CA2 P00918 1/20 0.61
PARP1 P09874 1/20 0.61
PARP10 Q53GL7 1/20 0.61
PARP2 Q9UGN5 1/20 0.61
PARP4 Q9UKK3 1/20 0.61
TMPRSS2 O15393 1/20 0.57
PRMT1 Q99873 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2570665 0.98 PRSS1 (0.95) PRSS1PRSS2PRSS3PTGIRNQO2
SCHEMBL15293729 0.94 PRSS1 (0.88) PRSS1PRSS2PRSS3PTGIRNQO2
SCHEMBL9852193 0.92 PRSS1 (0.84) PRSS1PRSS2PRSS3PTGIRNQO2
SCHEMBL9852190 0.90 PRSS1 (0.81) PRSS1PRSS2PRSS3PTGIRNQO2
SCHEMBL5788625 0.88 PTGIR (1.00) PRSS1PRSS2PRSS3PTGIRNQO2
SCHEMBL10890871 0.85 PRSS1 (0.72) PRSS1PRSS2PRSS3PTGIRNQO2
SCHEMBL14599566 0.84 NQO2 (1.00) PRSS1PRSS2PRSS3PTGIRNQO2
Hydrochloric Acid SCHEMBL30859643 0.82 ALDH1A1 (0.74) PRSS1PRSS2PRSS3PTGIRNQO2
SCHEMBL31546801 0.81 PRSS1 (0.68) PRSS1PRSS2PRSS3PTGIRNQO2
SCHEMBL3368290 0.81 PRSS1 (0.68) PRSS1PRSS2PRSS3PTGIRNQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250003975-A1 Systems and Methods for Performing a Real-Time Glycan Assay of a Sample AMGEN INC. (US) 2025-01-02 US claimed
CN-110892267-B System and method for real-time glycan determination of a sample 安进公司 2024-08-09 CN claimed
EP-3662288-B1 SYSTEMS AND METHODS FOR PERFORMING A REAL-TIME GLYCAN ASSAY OF A SAMPLE AMGEN INC (US) 2024-02-28 EP claimed
CN-113383039-B Moisture curable polyolefin formulation 陶氏环球技术有限责任公司 2023-09-26 CN claimed
US-20220098432-A1 MOISTURE-CURABLE POLYOLEFIN FORMULATION DOW GLOBAL TECHNOLOGIES LLC (US) 2022-03-31 US claimed
EP-3924083-A1 SYSTEMS AND METHODS FOR PREPARING A SAMPLE AND PERFORMING A REAL-TIME ASSAY OF THE SAMPLE Amgen Inc. (US) 2021-12-22 EP claimed
EP-3924419-A1 MOISTURE-CURABLE POLYOLEFIN FORMULATION Dow Global Technologies LLC (US) 2021-12-22 EP claimed
CN-113383039-A Moisture curable polyolefin formulations 陶氏环球技术有限责任公司 2021-09-10 CN claimed
WO-2020164004-A1 MOISTURE-CURABLE POLYOLEFIN FORMULATION DOW GLOBAL TECHNOLOGIES LLC (US) 2020-08-20 WO claimed
WO-2020168156-A1 SYSTEMS AND METHODS FOR PREPARING A SAMPLE AND PERFORMING A REAL-TIME ASSAY OF THE SAMPLE AMGEN INC. (US) 2020-08-20 WO claimed
EP-3662288-A1 SYSTEMS AND METHODS FOR PERFORMING A REAL-TIME GLYCAN ASSAY OF A SAMPLE Amgen Inc. (US) 2020-06-10 EP claimed
CN-110892267-A Systems and methods for real-time glycan determination of a sample 安进公司 2020-03-17 CN claimed
WO-2019028191-A9 SYSTEMS AND METHODS FOR PERFORMING A REAL-TIME GLYCAN ASSAY OF A SAMPLE AMGEN INC. (US) 2020-01-09 WO claimed
WO-2019028191-A1 SYSTEMS AND METHODS FOR PERFORMING A REAL-TIME GLYCAN ASSAY OF A SAMPLE AMGEN INC. (US) 2019-02-07 WO claimed
EP-4397977-B1 SYSTEMS AND METHODS FOR PREPARING A SAMPLE AND PERFORMING A REAL-TIME ASSAY OF THE SAMPLE AMGEN INC (US) 2026-04-29 EP disclosed
US-12352755-B2 Systems and methods for preparing a sample and performing a real-time assay of the sample AMGEN INC. (US) 2025-07-08 US disclosed
US-20250057957-A1 SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION C4 THERAPEUTICS, INC. (US) 2025-02-20 US disclosed
US-4874546-A LIQUID CRYSTALS CHISSO CORPORATION (JP) 1989-10-17 US disclosed
US-4598149-A ADRENERGIC BLOCKING AGENTS MERCK & CO., INC. (US) 1986-07-01 US disclosed
EP-0153746-A2 3-Amino-2-hydroxypropyl derivatives of pyrimidin-4-one MERCK & CO. INC. (US) 1985-09-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250057957-A1 SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION STUB1, UBE3C, UBE3A PRSS1 2385/4885PRSS2 3295/4885PRSS3 3209/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.