Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.52 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.52 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.52 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.52 |
| ▸ | NOS3 | P29474 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTGIR | P43119 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1839897 | 1.00 | CA1 (0.52) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL10925317 | 0.81 | CA1 (0.67) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL29008518 | 0.79 | CA1 (0.59) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL201860 | 0.77 | CA1 (0.61) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL10045847 | 0.74 | CES2 (0.56) | CA1CA2PARP10PRSS1PRSS2 | |
| Acetic Acid SCHEMBL28394298 | 0.73 | CA1 (0.62) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL3448365 | 0.72 | CES2 (0.58) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL1837474 | 0.72 | CA1 (0.50) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL1837473 | 0.72 | CA1 (0.50) | CA1CA2PARP10PRSS1PRSS2 | |
| SCHEMBL237978 | 0.71 | CES2 (0.52) | CA1CA2PARP10PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960419-B2 | Substituted carboxamides | ELI LILLY AND COMPANY (US) | 2011-06-14 | — | — | US | disclosed |
| EP-2076502-B1 | SUBSTITUTED CARBOXAMIDES AS GROUP I METABOTROPIC RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2011-05-18 | — | — | EP | disclosed |
| US-20090182025-A1 | SUBSTITUTED CARBOXAMIDES | ELI LILLY AND COMPANY | 2009-07-16 | — | — | US | disclosed |
| EP-2076502-A2 | SUBSTITUTED CARBOXAMIDES AS GROUP I METABOTROPIC RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008103185-A2 | SUBSTITUTED CARBOXAMIDES AS GROUP I METABOTROPIC RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090182025-A1 | SUBSTITUTED CARBOXAMIDES | CNR2, TRPV1, CNR1 | CA1 853/4885CA2 64/4885PARP10 1351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.