Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10925296 | 0.88 | ATM (0.39) | KMT2AHPGDALDH1A1MEN1NPC1 | |
| SCHEMBL10922810 | 0.86 | TSHR (0.48) | HPGDALDH1A1MAPTSMN1; SMN2SMPD1 | |
| SCHEMBL10926682 | 0.83 | MAPT (0.51) | KMT2AHPGDALDH1A1MEN1MAPT | |
| SCHEMBL3853732 | 0.81 | KDM4E (0.44) | KMT2AHPGDALDH1A1MEN1NPC1 | |
| SCHEMBL4781509 | 0.80 | ALDH1A1 (0.43) | KMT2AHPGDALDH1A1MEN1NPC1 | |
| SCHEMBL10926602 | 0.79 | NPC1 (0.56) | KMT2AALDH1A1MEN1NPC1MAPT | |
| SCHEMBL1324894 | 0.75 | POLB (0.48) | KMT2AHPGDALDH1A1MEN1NPC1 | |
| SCHEMBL4034138 | 0.74 | NPC1 (0.65) | HPGDALDH1A1NPC1MAPTPKM | |
| SCHEMBL8114735 | 0.73 | HDAC6 (0.66) | KMT2AHPGDALDH1A1MEN1NPC1 | |
| SCHEMBL10926847 | 0.73 | MAPT (0.43) | HPGDALDH1A1MAPTSMN1; SMN2SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189080-A2 | (1,2,4-Oxadiazol-3-YL)-arylmethanones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-07-30 | — | — | EP | claimed |
| US-4562186-A | HYPOTENSIVE, ANALGESICS, AND ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | claimed |
| EP-0189080-A2 | (1,2,4-Oxadiazol-3-YL)-arylmethanones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-07-30 | — | — | EP | disclosed |
| US-4562186-A | HYPOTENSIVE, ANALGESICS, AND ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | disclosed |