Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11187980 | 0.88 | ATM (0.47) | ATMADRA1BHTR1ALMNAGAA | |
| SCHEMBL10916147 | 0.87 | ATM (0.47) | ATMADRA1BHTR1ALMNAGAA | |
| Hydrochloric Acid SCHEMBL10919243 | 0.85 | ABCB1 (0.48) | ATMADRA1BHTR1ALMNAHTR7 | |
| Hydrochloric Acid SCHEMBL10925180 | 0.84 | TSHR (0.50) | ADRA1BHTR1ALMNAHTTADRA1D | |
| SCHEMBL10929534 | 0.84 | ATM (0.44) | ATMADRA1BHTR1ALMNAGAA | |
| Hydrochloric Acid SCHEMBL10925998 | 0.84 | KDM4E (0.48) | ATMHTR1ALMNAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10921685 | 0.82 | ABCB1 (0.43) | ATMADRA1BHTR1ALMNAKDM4E | |
| Hydrochloric Acid SCHEMBL10921255 | 0.82 | PDE3B (0.52) | ATMADRA1BHTR1ALMNAKDM4E | |
| SCHEMBL10919669 | 0.81 | NPC1 (0.50) | HTR1ALMNAHTTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10918826 | 0.81 | DRD2 (0.49) | ATMADRA1BHTR1ALMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064705-B1 | 5-AMINOMETHYL-2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-18 | — | — | EP | disclosed |
| US-4371737-A | CARDIOTONICS, ANTIHYPERTENSIUES AND ANTITHROMBOTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-02-01 | — | — | US | disclosed |
| EP-0064705-A1 | 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |