Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10916147 | 0.86 | ATM (0.47) | ATMHTR1AADRA1BKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11187980 | 0.84 | ATM (0.47) | ATMHTR1AADRA1BKDM4EALDH1A1 | |
| SCHEMBL10925703 | 0.84 | ATM (0.47) | ATMHTR1AADRA1BKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10925998 | 0.83 | KDM4E (0.48) | ATMHTR1AKDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL10919243 | 0.82 | ABCB1 (0.48) | ATMHTR1AADRA1BKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10923347 | 0.79 | ABCB1 (0.42) | ATMHTR1AADRA1BKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10921685 | 0.78 | ABCB1 (0.43) | ATMHTR1AADRA1BKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10921255 | 0.78 | PDE3B (0.52) | ATMHTR1AADRA1BKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10918826 | 0.78 | DRD2 (0.49) | ATMHTR1AADRA1BKDM4EALDH1A1 | |
| SCHEMBL10919669 | 0.78 | NPC1 (0.50) | HTR1AKDM4EALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064705-B1 | 5-AMINOMETHYL-2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-18 | — | — | EP | disclosed |
| US-4371737-A | CARDIOTONICS, ANTIHYPERTENSIUES AND ANTITHROMBOTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-02-01 | — | — | US | disclosed |
| EP-0064705-A1 | 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |