SCHEMBL1092575

SCHEMBL1092575

O=C(O)Nc1cc(Cl)ccc1Cl

nearest known ligand 0.69

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.69
KMT2A Q03164 5/20 0.69
POLB P06746 1/20 0.69
EPHX1 P07099 2/20 0.57
MAPT P10636 1/20 0.57
CYP2C19 P33261 1/20 0.55
IDO1 P14902 1/20 0.55
PDK1 Q15118 1/20 0.54
PDK2 Q15119 1/20 0.54
PDK3 Q15120 1/20 0.54
PDK4 Q16654 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.51
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
ALDH1A1 P00352 1/20 0.50
TP53 P04637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1092441 0.83 KDM4E (0.58) POLBCYP2C19PDK1PDK2PDK3
SCHEMBL9836674 0.83 MEN1 (0.69) MEN1KMT2APOLBEPHX1MAPT
SCHEMBL11402386 0.82 PDK1 (0.59) MEN1KMT2APOLBMAPTCYP2C19
SCHEMBL29177448 0.82 GRIK1 (0.54) MEN1KMT2APOLBMAPTL3MBTL1
SCHEMBL5150505 0.82 MEN1 (0.67) MEN1KMT2APOLBEPHX1MAPT
SCHEMBL2388970 0.82 EPHX1 (0.70) MEN1KMT2APOLBEPHX1MAPT
SCHEMBL9170975 0.82 POLB (0.71) MEN1KMT2APOLBCA1CA2
SCHEMBL1068813 0.82 GAA (0.65) MEN1KMT2APOLBMAPTALDH1A1
SCHEMBL29791333 0.82 GRIK1 (0.54) MEN1KMT2APOLBMAPTL3MBTL1
SCHEMBL2229391 0.80 ACLY (0.46) MEN1KMT2APOLBMAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106220576-A A kind of synthetic method of clozapine key intermediate 常州大学 2016-12-14 CN claimed
US-8153551-B2 Optical isomer separating filler DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2012-04-10 US claimed
US-20100041878-A1 Optical Isomer separating filler DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2010-02-18 US claimed
EP-2113769-A1 OPTICAL ISOMER SEPARATING FILLER Daicel Chemical Industries, Ltd. (JP) 2009-11-04 EP claimed
EP-1212295-B1 SUBSTITUTED ALPHA-HYDROXY ACID CASPASE INHIBITORS AND THE USE THEREOF CYTOVIA INC (US) 2008-10-01 EP claimed
US-12403447-B2 Separating agent for optical isomers DAICEL CORPORATION (JP) 2025-09-02 US disclosed
US-20210370270-A1 SEPARATING AGENT FOR OPTICAL ISOMERS DAICEL CORPORATION (JP) 2021-12-02 US disclosed
US-20180085734-A1 SEPARATING AGENT FOR OPTICAL ISOMERS DAICEL CORPORATION (JP) 2018-03-29 US disclosed
CN-106220576-A A kind of synthetic method of clozapine key intermediate 常州大学 2016-12-14 CN disclosed
US-8153551-B2 Optical isomer separating filler DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2012-04-10 US disclosed
US-20100041878-A1 Optical Isomer separating filler DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2010-02-18 US disclosed
EP-2113769-A1 OPTICAL ISOMER SEPARATING FILLER Daicel Chemical Industries, Ltd. (JP) 2009-11-04 EP disclosed