SCHEMBL109259

SCHEMBL109259

COC(C(=O)O)c1c[nH]c(=O)[nH]c1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.40
ATAD2 Q6PL18 1/20 0.40
ALDH1A1 P00352 4/20 0.36
POLB P06746 3/20 0.36
CYP1A2 P05177 1/20 0.36
LMNA P02545 3/20 0.36
MAPT P10636 2/20 0.36
DPYD Q12882 2/20 0.36
CYP19A1 P11511 1/20 0.36
TSHR P16473 1/20 0.36
THPO P40225 1/20 0.36
MTOR P42345 1/20 0.36
HTT P42858 1/20 0.36
HBB P68871 1/20 0.36
PMP22 Q01453 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
TP53 P04637 1/20 0.35
KDM4E B2RXH2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28699194 0.77 GAA (0.44) GAAATAD2ALDH1A1POLBCYP1A2
SCHEMBL38658521 0.77 ATAD2 (0.47) GAAATAD2ALDH1A1LMNAMAPT
SCHEMBL103606 0.75 GAA (0.45) GAAATAD2ALDH1A1CYP1A2LMNA
SCHEMBL15798548 0.75 ALDH1A1 (0.36) GAAATAD2ALDH1A1POLBCYP1A2
SCHEMBL27500671 0.74 ALDH1A1 (0.44) GAAATAD2ALDH1A1CYP1A2LMNA
SCHEMBL19668130 0.73 GAA (0.40) GAAATAD2ALDH1A1POLBCYP1A2
SCHEMBL5059885 0.73 GAA (0.40) GAAATAD2ALDH1A1POLBCYP1A2
SCHEMBL15798550 0.73 POLB (0.36) GAAATAD2ALDH1A1POLBCYP1A2
SCHEMBL27482031 0.72 LMNA (0.39) GAAATAD2ALDH1A1POLBCYP1A2
SCHEMBL16893950 0.72 GAA (0.54) GAAATAD2ALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 13380 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250257360-A1 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER UNIV OKLAHOMA (US) 2025-08-14 US claimed
EP-4504945-A2 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER The Board of Regents of the University of Oklahoma (US) 2025-02-12 EP claimed
US-12146139-B2 Oligonucleotide interference treatments of prostate cancer THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2024-11-19 US claimed
CN-117778530-A Method for adding preset joint to 5' end of single-stranded DNA 清华大学 2024-03-29 CN claimed
WO-2023196944-A2 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2023-10-12 WO claimed
US-20230235339-A1 IMPORT OF UNNATURAL OR MODIFIED NUCLEOSIDE TRIPHOSPHATES INTO CELLS VIA NUCLEIC ACID TRIPHOSPHATE TRANSPORTERS THE SCRIPPS RESEARCH INSTITUTE 2023-07-27 US claimed
US-20230148152-A1 METHOD OF SYNTHESIZING SINGLE-STRANDED NUCLEOTIDE SEQUENCE, BLOCKED NUCLEOSIDE TRIPHOSPHATES AND RELATED METHODS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-05-11 US claimed
EP-4058152-A1 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER The Board of Regents of the University of Oklahoma (US) 2022-09-21 EP claimed
US-20220275374-A1 OLIGONUCLEOTIDE INTERFERENCE TREATMENTS OF PROSTATE CANCER THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA 2022-09-01 US claimed
CN-114761026-A Compositions and methods for in vivo synthesis of non-native polypeptides 斯克利普斯研究所 2022-07-15 CN claimed
US-20170015667-A1 THIOL-X CLICK FOLDAMERS FOR POLYMER AFFINITY AND CATALYSIS LIBRARIES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-01-19 US claimed
US-20160264958-A1 COMPOSITIONS AND METHODS FOR SYNTHETIC GENE ASSEMBLY Twist Bioscience Corporation 2016-09-15 US claimed
US-9333218-B2 MicroRNA compositions and methods related thereto EMORY UNIVERSITY (US) 2016-05-10 US claimed
WO-2015157555-A2 IMPORT OF UNNATURAL OR MODIFIED NUCLEOSIDE TRIPHOSPHATES INTO CELLS VIA NUCLEIC ACID TRIPHOSPHATE TRANSPORTERS THE SCRIPPS RESEARCH INSTITUTE (US) 2015-10-15 WO claimed
US-8895719-B2 Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein ANDES BIOTECHNOLOGIES S.A. (CL) 2014-11-25 US claimed
US-20130149371-A1 MARKERS FOR PRE-CANCER AND CANCER CELLS AND THE METHOD TO INTERFERE WITH CELL PROLIFERATION THEREIN ANDES BIOTECHNOLIGIES S.A. (CL) 2013-06-13 US claimed
EP-1295130-A2 NIMR COMPOSITIONS AND THEIR METHODS OF USE TRUSTEES OF TUFTS COLLEGE (US) 2003-03-26 EP claimed
WO-2001070776-A2 NIMR COMPOSITIONS AND THEIR METHODS OF USE TRUSTEES OF TUFTS COLLEGE (US) 2001-09-27 WO claimed
WO-1998042723-A9 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF NEUROPSYCHIATRIC DISORDERS 1999-03-04 WO claimed
US-5486603-A Oligonucleotide having enhanced binding affinity GILEAD SCIENCES, INC. (US) 1996-01-23 US claimed