Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Acridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.50 |
| ▸ | PRNP | P04156 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | MGAM | O43451 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenazine SCHEMBL8940300 | 0.88 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTKDM4ERXFP1 | |
| Anthracene SCHEMBL27602514 | 0.86 | TP53 (0.52) | ALDH1A1HPGDGLAKDM4EGAA | |
| Acridine SCHEMBL11500721 | 0.84 | MAPT (0.68) | ALDH1A1HPGDGLAMAPTACHE | |
| Lactic Acid SCHEMBL5515418 | 0.83 | ALDH1A1 (0.44) | ALDH1A1HPGDGLAMAPTACHE | |
| Lactic Acid SCHEMBL28885529 | 0.82 | ALDH1A1 (0.43) | ALDH1A1HPGDGLAMAPTACHE | |
| Naphthalene SCHEMBL28289269 | 0.81 | TP53 (0.58) | ALDH1A1KDM4ERXFP1PRNPNPSR1 | |
| Acridine SCHEMBL8643076 | 0.79 | ALDH1A1 (0.68) | ALDH1A1HPGDGLAMAPTACHE | |
| Acridine SCHEMBL4854060 | 0.79 | ALDH1A1 (0.68) | ALDH1A1HPGDGLAMAPTACHE | |
| Acridine SCHEMBL27603600 | 0.78 | ALDH1A1 (0.94) | ALDH1A1HPGDGLAMAPTACHE | |
| Quinoline SCHEMBL27820159 | 0.78 | ALDH1A1 (0.61) | ALDH1A1MAPTKDM4ERXFP1PRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458847-A | Novel diamine synthesis and liquid crystal aligning agent using the same | 东进世美肯株式会社 | 2017-02-22 | — | — | CN | claimed |
| CN-103702976-B | Amine compound, preparation method thereof, liquid crystal alignment agent, liquid crystal alignment film and liquid crystal display element | DONGJIN SEMICHEM CO.,LTD. (KR) | 2016-04-20 | — | — | CN | claimed |
| CN-103649199-B | Photoactive crosslinking compound, preparation method thereof, liquid crystal alignment agent, liquid crystal alignment film and liquid crystal display element | DONGJIN SEMICHEM CO.,LTD. (KR) | 2015-11-25 | — | — | CN | claimed |
| CN-103748068-B | Diamine compound, preparation method thereof, liquid crystal alignment agent, liquid crystal alignment film and liquid crystal display element | DONGJIN SEMICHEM CO.,LTD. (KR) | 2015-08-05 | — | — | CN | claimed |
| CN-103748068-A | Diamine compound, preparation method thereof, liquid crystal alignment agent, liquid crystal alignment film and liquid crystal display element | DONGJIN SEMICOHEM CO LTD | 2014-04-23 | — | — | CN | claimed |
| CN-103702976-A | Amine compound, preparation method thereof, liquid crystal alignment agent, liquid crystal alignment film and liquid crystal display element | DONGJIN SEMICOHEM CO LTD | 2014-04-02 | — | — | CN | claimed |
| CN-103649199-A | Photoactive crosslinking compound, preparation method thereof, liquid crystal alignment agent, liquid crystal alignment film and liquid crystal display element | DONGJIN SEMICOHEM CO LTD | 2014-03-19 | — | — | CN | claimed |
| CN-101879283-B | Novel membrane spraying preparation for skin trauma and preparation method | UNIV PLA 3RD MILITARY MEDICAL | 2013-01-02 | — | — | CN | claimed |
| CN-101879283-A | Novel membrane spraying preparation for skin trauma and preparation method | UNIV PLA 3RD MILITARY MEDICAL | 2010-11-10 | — | — | CN | claimed |
| CN-109364053-A | A kind of small molecule compound is preparing the application in anti-silkworm baculovirus infection medicine | 江苏科技大学 | 2019-02-22 | — | — | CN | disclosed |
| CN-109223784-A | Application of the small molecule compound in preparation silkworm antiviral drugs | 江苏科技大学 | 2019-01-18 | — | — | CN | disclosed |
| CN-106458847-A | Novel diamine synthesis and liquid crystal aligning agent using the same | 东进世美肯株式会社 | 2017-02-22 | — | — | CN | disclosed |
| CN-103702976-B | Amine compound, preparation method thereof, liquid crystal alignment agent, liquid crystal alignment film and liquid crystal display element | DONGJIN SEMICHEM CO.,LTD. (KR) | 2016-04-20 | — | — | CN | disclosed |
| CN-103649199-B | Photoactive crosslinking compound, preparation method thereof, liquid crystal alignment agent, liquid crystal alignment film and liquid crystal display element | DONGJIN SEMICHEM CO.,LTD. (KR) | 2015-11-25 | — | — | CN | disclosed |
| CN-1718675-A | Liquid crystal orientating agent and liquid crystal display element | JSR CORP (JP) | 2006-01-11 | — | — | CN | disclosed |
| CN-1718674-A | Liquid crystal orientating agent and liquid crystal display element | JSR CORP (JP) | 2006-01-11 | — | — | CN | disclosed |
| CN-1712491-A | Veertical liquid crystal orienting agent and vertical liquid crystal display element agent | JSR CORP (JP) | 2005-12-28 | — | — | CN | disclosed |
| CN-1690164-A | Vertical orientated liquid crystal orientation agent and liquid crystal display member | JSR CORP (JP) | 2005-11-02 | — | — | CN | disclosed |
| CN-1564840-A | Diamine compound, polyamic acid, imide polymer, liquid crystal alignment agent and liquid crystal display | JSR CO LTD (JP) | 2005-01-12 | — | — | CN | disclosed |
| US-4508830-A | MIXING SAMPLE SOLUTION, TWO ANTIBODIES CAPABLE OF REVERSE BBINDING, LABELED ANTIBODY AND LIGAND | BOOTS-CELLTECH DIAGNOSTICS LIMITED (GB) | 1985-04-02 | — | — | US | disclosed |