Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | PRNP | P04156 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL28885529 | 0.99 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDKMT2APOLB | |
| SCHEMBL29562242 | 0.88 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDKMT2APOLB | |
| SCHEMBL28201815 | 0.88 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDKMT2APOLB | |
| Acridine SCHEMBL10926258 | 0.83 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDKMT2APOLB | |
| SCHEMBL22739301 | 0.80 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDKMT2APOLB | |
| Butanol SCHEMBL28277039 | 0.78 | TLR8 (0.44) | ALDH1A1KDM4EHPGDKMT2APOLB | |
| SCHEMBL9727747 | 0.77 | TDP1 (0.64) | ALDH1A1KDM4EHPGDKMT2APOLB | |
| Phenazine SCHEMBL8940300 | 0.76 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDKMT2ALMNA | |
| Lactic Acid SCHEMBL1720338 | 0.76 | TLR8 (0.45) | ALDH1A1KDM4EHPGDKMT2APOLB | |
| SCHEMBL28282239 | 0.75 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070077625-A1 | Adding to the microbial fermentation broth or homogenate, a solution of 6,9-diamino-2-ethoxyacridine lactate (ethacridine lactate) to precipitate host cell impurities, polypeptide remains soluble, separating the desiered polypeptide | LESTER PHILIP M | 2007-04-05 | — | — | US | claimed |
| US-7169908-B2 | Purification of polypeptides | GENENTECH, INC. (US) | 2007-01-30 | — | — | US | claimed |
| EP-1581644-A1 | PURIFICATION OF POLYPEPTIDES | Genentech, Inc. (US) | 2005-10-05 | — | — | EP | claimed |
| US-20050037456-A1 | Purification of polypeptides | GENENTECH, INC. | 2005-02-17 | — | — | US | claimed |
| WO-2004092393-A1 | PURIFICATION OF POLYPEPTIDES | GENENTECH, INC. (US) | 2004-10-28 | — | — | WO | claimed |